1) Graduate School of Agricultural and Life Sciences, The University of Tokyo 2) MiZ Co., Ltd.3) Food Safety and Reliability Project, Kanagawa Academy of Science and Technology4) Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
(Received November 19, 2010) (Accepted December 27, 2010)
The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.
