氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气治疗应激引起的神经损伤

已有 6396 次阅读 2009-2-10 18:06 |个人分类:饮用氢气水|系统分类:科研笔记|关键词:氢气,论文,氢分子医学| 论文, 氢气, 氢分子医学

日本学者发现,给动物饮用含氢水可以改善应激导致的神经损伤.

2008年7月19日 ... 日医大教授藉由动物实验发现喝含氢水可以抑制计记忆力降低, 这项对于打开认知症预防和治疗之门的成果报告在美国科学杂志电子板上发表。

 

这个文章是首先报道的含氢水的文献, 文章以学习记忆能力和神经干细胞为指标进行了研究. 研究比较系统,值得阅读

: Neuropsychopharmacology. 2009 Jan;34(2):501-8. Epub 2008 Jun 18.Click here to read Links

Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.

Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara-ku, Kawasaki, Japan.

We have reported that hydrogen (H(2)) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several microM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydrogen gas, prevents cognitive impairment by reducing oxidative stress. Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the brain, and impaired learning and memory, as judged by three different methods: passive avoidance learning, object recognition task, and the Morris water maze. Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. Neural proliferation in the dentate gyrus of the hippocampus was suppressed by restraint stress, as observed by 5-bromo-2'-deoxyuridine incorporation and Ki-67 immunostaining, proliferation markers. The consumption of hydrogen water ameliorated the reduced proliferation although the mechanistic link between the hydrogen-dependent changes in neurogenesis and cognitive impairments remains unclear. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint. Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders

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