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这篇论文已正式发表在《Food Science and Human Wellness》(《食品科学与人类健康》,中国食品杂志社),题目是:“Research progress of gut flora in improving human wellness(肠道菌群促进人类健康研究进展)”,欢迎大家下载阅读全文并批评指正!
https://doi.org/10.1016/j.fshw.2019.03.007
https://www.sciencedirect.com/science/article/pii/S2213453019300278
Volume 8, Issue 2, June 2019, Pages 102-105
Chenggang Zhang, Wenjing Gong, Zhihui Li, Dawen Gao, Yan Gao
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https://doi.org/10.1016/j.fshw.2019.03.007Get rights and content
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Human wellness is the ultimate goal of our efforts in improving the human life. Special foods are undoubtedly important in achieving human wellness. However, overeating significantly leads to obesity and diabetes. These chronic diseases will in turn affect the human wellness. Therefore, “dietary restriction and proper exercise” were introduced in the human daily life. Different foods cause various effects on the human health. The diversification of diet is a priority for nutritionists to keep our body healthy. To avoid diabetes mellitus, special foods for ketogenic diet, low-carbon diet, and low-calorie intake are also gradually attracting attention. In addition, the hypothesis that “hunger sensation comes from gut flora” brings new light to the research on the biological motivation for humans to eat food. This hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods, such as plant polysaccharides and dietary fibers. The response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human wellness. The gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our body. Therefore, “gut flora priority principle” is developed to guarantee human wellness. The 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora, which may guide us to a new era of human wellness based on gut flora wellness.
Hunger sensation comes from gut flora
Gut flora-centric theory
Flexible fasting
Gut flora priority principle
Universal reproducing power of the microbiota
Gut flora wellness
Human wellness
Food-eating behavior is important in our daily life. Usually, the eating behavior of humans includes breakfast, lunch, and dinner in a day in most countries. Different countries exhibit varying tendencies for food styles and various cooking cultures. As one of the ancient countries, China features about 5000 years of cooking cultures. Compared with the fast-food cultures, for example, in America, the Chinese foods are welcome in most countries. However, in recent years, the urgently increasing chronic diseases indicate the problems in unhealthy eating behaviors or unsafe foods. The relationships between foods and health are extremely important in the prevention and control of chronic diseases as documented in a large number of literature [[1], [2], [3], [4], [5], [6], [7], [8], [9]]. For a long time, our laboratory focused on the study of molecular mechanisms underlying the chronic diseases, such as strokeand ischemia injuries, in recent years; however, finding the etiology of chronic diseases poses difficulty [[10], [11], [12]]. Given the rapid progresses in the field of gut flora study and chronic diseases, we queried whether a direct and hidden link to the gut flora probably exists between special foods and the human health. Different foods correspond to various gut flora, whereas different gut flora correspond to distinct diseases, as indicated in an increasing number of literature [[13], [14], [15], [16]]. Therefore, a new model named “gut flora-centric theory (GFCT)” was then developed based on these studies and our own research. The GFCT model will probably provide a new understanding and explanation to bridge the special foods and human wellness.
At first, we will briefly introduce the concept of “GFCT”. The GFCT is a new hypothesis focusing on the biological motivation of why humans need to eat food every day. Almost from the beginning of the human society, humans were told to eat food. Of course, if food is unavailable, then the uncontrollable hunger sensation and accompanying hypoglycemia will result in unexpected body injuries. Therefore, as an important matter regarding the human eating behavior, a few people ask this question: what are the biological basis and motivation for humans to eat foods? Starting from 2013, as an obese man myself with a body mass index higher than 34, I used my own body to test how to control the body weight following the suggestions by Dr. Liping Zhao in Science [[17], [18], [19], [20], [21], [22], [23]] and the related studies on obesity and the gut flora by Dr. Gordon JI [[24], [25], [26], [27], [28], [29], [30], [31]]. Immediately afterward, I gradually discovered that my hunger sensation seemed to originate from the gut flora, because when I ingest special foods, such as plant polysaccharides and dietary fibers, to feed the gut flora but provided no food for my own body through three meals a day, my hunger sensation gradually diminished and disappeared. Not only my body weight but also my diabetes mellitus and severe fatty liver were significantly improved. Shortly thereafter, the related clinical trials based on the flexible fasting (FF) technology were initiated and have been successfully completed [[32], [33], [34], [35], [36], [37], [38]]. By carefully analyzing and examining the important clinical results, we finally proposed the new finding that “hunger sensation comes from gut flora” because of the “universal reproducing power of the microbiota” living in the gastrointestinal tract after birth [39]. Therefore, we unexpectedly discovered that the food-eating signals originate from the gut flora but not from the cerebral feeding center with neural circuits of motivation to control food intake, which is current knowledge [40]. When we used the FF technology to control the hunger sensation, the volunteers can normally live for 7–14 days without human food but only food for the gut flora and 3–5 L of water every day, similar to camels living in the desert [33,34,[41], [42], [43]]. This kind of lifestyle can directly benefit obese people because the human body can then automatically burn the internal fat to provide energy [33]. In short, the gut flora controls the hunger sensation of human beings. Detailed introductions on the GFCT theory have been reported recently [38,39].
After the GFCT theory was proposed and developed in recent years [33,38,39], we pondered on the relationship between the gut flora and human beings. The human body is now widely accepted as a symbiotic structure working together with the microbiota within our body [44,45], with more than 90% of the microorganismsliving in our gut (mostly in the large intestine) [46,47]. The human genomic DNA is the 1st genomic DNA (termed as operating system 1, OS/1), whereas the symbiotic microorganism genomic DNA is the 2nd genomic DNA system (termed as operating system 2, OS/2) [39,45]. Therefore, the human body could be regarded as a two-genomic-DNA-driven system, with the OS/1 as host and the OS/2 including the symbiotic microorganisms (mostly in the gut flora). Animals are carnivores, omnivores, or herbivores [48]. Different gut flora structures exist in animals with specific food preferences [49,50]. Similarly, in humans, food preference is also frequently observed. Some people opt for a vegetarian lifestyle for their beliefs, whereas others show no specific preference for different kinds of food [51]. Considerably extreme food preference will result in allotriophagia [52]. Fortunately, the 16S rRNA sequencing technology could be used to identify the metagenomicsinformation on the gut flora and determine whether the gut flora is normal or abnormal [[53], [54], [55]]. Together with the viewpoint of the GFCT theory, the food preference information is probably recorded and memorized by the gut flora. If such is the case, then the gut flora functions as the interpreter for transmitting the food preference signals to the human brain via the vagus [[56], [57], [58]]. Theoretically, when the gut flora needs a carbon source for energy to reproduce in the human gut under the control of “universal reproducing power of the microbiota,” then the hunger sensation signals will be sent from the gut to the brain. Therefore, for biological reasons, the food-eating behavior primarily aims to meet the food-needing signals of the gut flora. Different gut floras memorize various types of foods [39]. If suitable foods are available to match the memories of the gut flora, then the gut flora will help the human body to digest the food to produce nutrition not only for themselves but also for the human body.
Human wellness is the first-of-all pursuit for everybody. However, what are the best foods for achieving human wellness? According to the above discussion, based on the GFCT theory, the human wellness should include three parts: (1) wellness of the human body; (2) wellness of the gut flora; (3) maximum matching of the best foods and healthy gut flora (Fig. 1). Therefore, we prefer the “gut flora priority principle (GFPP)” in our daily lives when considering food preferences and eating behaviors[38,59]. In detail, as the biological motivation of human beings to eat food originates from the gut flora, then feeding the gut flora is a priority. Therefore, we should provide special foods, such as prebiotics, to first meet the need of the gut flora and food for our body next [[60], [61], [62]]. Adequate food should at least be available for the gut flora to guarantee its wellness. Otherwise, the gut flora will malfunction and fail to correctly transmit the food-eating signals toward the brain. In short, satisfying the gut flora is the first priority, and satisfying the human body comes second. The human wellness needs the gut flora wellness as the gut flora is the key point for hunger sensation and food-eating behavior.
Fig. 1
The best gut flora is critically important to bridge the direct link between the best foods and human wellness. Fortunately, the large-scale rRNA sequencing technology and mass spectrometry technique provide scientific and convenient approaches for this purpose. To identify whether a kind of food is suitable for human health, one of the best ways is to compare the differences in the gut flora in volunteers before and after using special foods. Usually, the 16S rRNA sequencing technology is sufficient to determine whether the gut flora improves or worsens [54]. The commercial companies can provide biological sample preparations from the feces and use the 16S rRNA sequencing and the following bioinformatic data analysis and interpretation for identification. On this basis, the use of any antibiotics will destroy the gut flora and directly result in body injuries [[63], [64], [65]].
Dividing foods into two types (one for the gut flora and the type for the human body) is important in daily life. Notably, all the foods for the human body can also be used by the gut flora. However, not all foods for the gut flora can be utilized by the human body. In this field, a large number of prebiotics, such as plant polysaccharides and dietary fibers, serve as food for the gut flora but could not be utilized by the human body [[66], [67], [68]]. The gut flora can decompose dietary fibers into short-chain fatty acids to provide nutrition for the intestinal epithelial cells, which will in turn support the wellness of the gut flora [[69], [70], [71]]. We have used the text mining approach to identify the novel prebiotics for further studies [72]. Normally, both the nutrition for the human body and gut flora, such as starch, rice, noodles, fruits, vegetables, fish, shrimps, meat, eggs, and milk, are combined together. The increased diversity of the nutrition indicates the increased diversity of the gut flora [[73], [74], [75]]. A gut flora with more diversity will provide the body with more abilities and capacities for digesting food and avoiding excessive food preference. Therefore, the foods with increased diversities must be ingested to keep the diversity of the gut flora to guarantee the wellness of human beings.
In this paper, we briefly introduced the GFCT theory and its potential application in food science to maintain the human wellness. Irregular eating behaviors and abnormal life styles will directly or indirectly injure the gut flora health and in turn influence the translation of foods into nutrition by the gut flora. Therefore, maintaining the gut flora health is critically important for digesting foods according to current studies. In addition, the suggestions of “dietary restriction and proper exercise” should be the golden rule and precept for human wellness, where the gut flora is the hidden factor for maintaining the human health. Altogether, we will probably enter a new era to enjoy human wellness based on the gut flora wellness and on the basis of the “GFPP” to develop and utilize special foods as specific nutrition sources for human wellness.
The authors declare that they have no competing interests.
This work was supported by the National Basic Research Project (973 program, 2012CB518200); General Program (81371232, 81573251) of the Natural Science Foundation of China; Special Key Programs for Drug R&D of China(2012ZX09102301-016, 2014ZX09J14107-05B); Foundation of Joint Research Center for Translational Medicine between Beijing Proteome Research Center and Tianjin Baodi Hospital (TMRC201301).
Y.C. Probst, V.X. Guan, K. KentDietary phytochemical intake from foods and health outcomes: a systematic review protocol and preliminary scoping
BMJ Open, 7 (2017), Article e013337
P. Roca-Saavedra, V. Mendez-Vilabrille, J.M. Miranda, et al.Food additives, contaminants and other minor components: effects on human an gut microbiota-a review
J. Physiol. Biochem., 74 (2018), pp. 69-83
M. Seminario-Amez, J. Lopez-Lopez, A. Estrugo-Devesa, et al.Probiotics and oral health: a systematic review
Med. Oral Patol. Oral Cirugia Bucal, 22 (2017), pp. e282-e288
E.S. Lee, E.J. Song, Y.D. Nam, et al.Probiotics in human health and disease: from nutribiotics to pharmabiotics
J. Microbiol., 56 (2018), pp. 773-782
C.S. Lin, C.J. Chang, C.C. Lu, et al.Impact of the gut microbiota, prebiotics, and probiotics on human health and disease
Biomed. J., 37 (2014), pp. 259-268
A. Zarrinpar, A. Chaix, S. PandaDaily eating patterns and their impact on health and disease
Trends Endocrinol. Metab., 27 (2016), pp. 69-83
C. Ekmekcioglu, P. Wallner, M. Kundi, et al.Red meat, diseases, and healthy alternatives: a critical review
Crit. Rev. Food Sci. Nutr., 58 (2018), pp. 247-261
N. Mourouti, M.D. Kontogianni, C. Papavagelis, et al.Diet and breast cancer: a systematic review
Int. J. Food Sci. Nutr., 66 (2015), pp. 1-42
R. Perez-Gregorio, J. Simal-GandaraA critical review of bioactive food components, and of their functional mechanisms, biological effects and health outcomes
Curr. Pharm. Des., 23 (2017), pp. 2731-2741
B. Jiang, C. Ren, Y. Li, et al.Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans
J. Biol. Inorg. Chem., 16 (2011), pp. 267-274
H. Li, C. Sun, Y. Wang, et al.Dynamic expression pattern of neuro-oncological ventral antigen 1 (Nova1) in the rat brain after focal cerebral ischemia/reperfusion insults
J. Histochem. Cytochem., 61 (2013), pp. 45-54
A. Shang, D. Zhou, L. Wang, et al.Increased neuroglobin levels in the cerebral cortex and serum after ischemia-reperfusion insults
Brain Res., 1078 (2006), pp. 219-226
S.N. Heinritz, E. Weiss, M. Eklund, et al.Intestinal microbiota and microbial metabolites are changed in a pig model fed a high-fat/low-fiber or a low-fat/high-fiber diet
PloS One., 11 (2016), Article e0154329
S.P. Shukla, J.G. Sanders, M.J. Byrne, et al.Gut microbiota of dung beetles correspond to dietary specializations of adults and larvae
Mol. Ecol., 25 (2016), pp. 6092-6106
C. Sala, S. Vitali, E. Giampieri, et al.Stochastic neutral modelling of the gut Microbiota’s relative species abundance from next generation sequencing data
BMC Bioinform., 17 (Suppl. 2) (2016), p. 16
S.A. Smits, A. Marcobal, S. Higginbottom, et al.Individualized responses of gut microbiota to dietary intervention modeled in humanized mice
mSystems, 1 (2016)
M. HvistendahlMy microbiome and me
Science, 336 (2012), pp. 1248-1250
J. Shen, M.S. Obin, L. ZhaoThe gut microbiota, obesity and insulin resistance
Mol. Aspects Med., 34 (2013), pp. 39-58
T. Wang, G. Cai, Y. Qiu, et al.Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
The ISME J., 6 (2012), pp. 320-329
L. ZhaoThe gut microbiota and obesity: from correlation to causality
Nat. Rev. Microbiol., 11 (2013), pp. 639-647
G. Wu, C. Zhang, J. Wang, et al.Diminution of the gut resistome after a gut microbiota-targeted dietary intervention in obese children
Sci. Rep., 6 (2016), p. 24030
X. Zhang, Y. Zhao, J. Xu, et al.Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats
Sci. Rep., 5 (2015), p. 14405
L. Zhao, J. ShenWhole-body systems approaches for gut microbiota-targeted, preventive healthcare
J. Biotechnol., 149 (2010), pp. 183-190
F. Backhed, H. Ding, T. Wang, et al.The gut microbiota as an environmental factor that regulates fat storage
Proc. Natl. Acad. Sci. U. S. A., 101 (2004), pp. 15718-15723
F. Backhed, R.E. Ley, J.L. Sonnenburg, et al.Host-bacterial mutualism in the human intestine
Science, 307 (2005), pp. 1915-1920
F. Backhed, J.K. Manchester, C.F. Semenkovich, et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Proc. Natl. Acad. Sci. U. S. A., 104 (2007), pp. 979-984
V.K. Ridaura, J.J. Faith, F.E. Rey, et al.Gut microbiota from twins discordant for obesity modulate metabolism in mice
Science, 341 (2013)
1241214
P.J. Turnbaugh, F. Backhed, L. Fulton, et al.Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
Cell Host Microbe, 3 (2008), pp. 213-223
P.J. Turnbaugh, M. Hamady, T. Yatsunenko, et al.A core gut microbiome in obese and lean twins
Nature, 457 (2009), pp. 480-484
P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, et al.An obesity-associated gut microbiome with increased capacity for energy harvest
Nature, 444 (2006), pp. 1027-1031
P.J. Turnbaugh, C. Quince, J.J. Faith, et al.Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins
Proc. Natl. Acad. Sci. U. S. A., 107 (2010), pp. 7503-7508
W. Gong, Q. Huang, D. Gao, et al.Application of flexible abrosia for body weight control among youths
Mil. Med., 40 (2016), pp. 651-656
W. Gong, C. Sun, S. Teng, et al.Evaluation of a novel fasting approach using plant polysaccharides per meal in human symbionts
Int. Clin. Med., 2 (2018), p. 12
Q. Huang, S. Teng, D. Gao, et al.Emergency plans of flexible abrosia to raise efficiency in disaster rescue
Disaster Med. Rescue (Electron. Ed.), 4 (2015), pp. 81-85
C. ZhangNew medicine and bacteriocentric theory and a revolution in prevention and control of chronic diseases
Sci. Technol. Rev., 33 (2015), pp. 106-111
C. ZhangHuman microecology, especially gut microflora provides unprecedented opportunities and challenges for new drug research and development
Chin. J. Pharmacol. Toxicol., 30 (2016), pp. 703-713
C. ZhangNew Medicine, Gut Flora-Centric Theory and Cloud Hospital
The Ancient Books Publishing House on Traditional Chinese Medicine, Beijing (2016)
C. Zhang, W. GongDiscovery based on hunger sensation comes from gut flora: breakthrough in chronic disease prevention and control
Sci. Technol. Rev., 35 (2017), p. 6
ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
C. ZhangThe gut flora-centric theory based on the new medical hypothesis of “hunger sensation comes from gut flora”: a new model for understanding the etiology of chronic diseases in human beings
Austin Int. Med., 3 (2018), p. 7
ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
C.R. Ferrario, G. Labouebe, S. Liu, et al.Homeostasis meets motivation in the battle to control food intake
J. Neurosci., 36 (2016), pp. 11469-11481
C. Zhang, W. GongFlexible bigu: a new approach for improving obesity and related chronic diseases
Med. J. Chin. People’s Health, 30 (2018), p. 3
Q. Ren, J. Huang, R. Huang, et al.Preliminary study on flexible abrosia technology to improve hypertension
Food Nutr. China, 23 (2017), pp. 70-75
N. Lu, W. Gong, Z. Li, et al.Preliminary research of flexible fasting on weight loss and improvement of hypertension and hyperglycemia
Med. J. Chin. People’s Health, 30 (2018), p. 4
K.E. Fujimura, N.A. Slusher, M.D. Cabana, et al.Role of the gut microbiota in defining human health
Expert Rev. Anti Infect. Ther., 8 (2010), pp. 435-454
P. Kramer, P. BressanHumans as superorganisms: how microbes, viruses, imprinted genes, and other selfish entities shape our behavior
Perspect. Psychol. Sci., 10 (2015), pp. 464-481
B. Zhu, X. Wang, L. LiHuman gut microbiome: the second genome of human body
Protein Cell., 1 (2010), pp. 718-725
C. Zhang, W. Gong, Z. Li, et al.Gut flora-centric theory of evolution: a new model for understanding the evolution of animals
Chin. J. Bioinform., 16 (2018), p. 11
ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
S. Kim, Y.S. Cho, H.M. Kim, et al.Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly
Genome Biol., 17 (2016), p. 211
ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
X. Chen, Q.Y. Li, G.D. Li, et al.The distal gut bacterial Community of some primates and carnivora
Curr. Microbiol., 75 (2018), pp. 213-222
C.D. Moon, W. Young, P.H. Maclean, et al.Metagenomic insights into the roles of proteobacteria in the gastrointestinal microbiomes of healthy dogs and cats
Microbiol. Open, 7 (2018), Article e00677
N.A. Pudlo, K. Urs, S.S. Kumar, et al.Symbiotic human gut bacteria with variable metabolic priorities for host mucosal glycans
mBio, 6 (2015), pp. e01282-01215
S.Q. Liu, P. Lei, Y. Lv, et al.Systematic review of gastrointestinal injury caused by magnetic foreign body ingestions in children and adolescence
Zhonghua wei chang wai ke za zhi, 14 (2011), pp. 756-761
A. Hiergeist, J. Glasner, U. Reischl, et al.Analyses of intestinal microbiota: culture versus sequencing
ILAR J., 56 (2015), pp. 228-240
A. Rapin, C. Pattaroni, B.J. Marsland, et al.Microbiota analysis using an illumina MiSeq platform to sequence 16S rRNA genes
Curr. Protocols Mouse Biol., 7 (2017), pp. 100-129
J. Wagner, P. Coupland, H.P. Browne, et al.Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification
BMC Microbiol., 16 (2016), p. 274
T.G. Dinan, J.F. CryanThe impact of gut microbiota on brain and behaviour: implications for psychiatry
Curr. Opin. Clin. Nutr. Metab. Care, 18 (2015), pp. 552-558
T.G. Dinan, J.F. CryanThe microbiome-gut-brain axis in health and disease
Gastroenterol. Clin. N. Am., 46 (2017), pp. 77-89
K.V. Sandhu, E. Sherwin, H. Schellekens, et al.Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry
Transl. Res., 179 (2017), pp. 223-244
C. Zhang, W. Gong, Z. Li, et al.Medical science version 3.0 (MS3.0) and health care management version 2.0 (HCM2.0) will significantly promote the strategy of healthy China
Eur. J. Transl. Med., 5 (2018), p. 17
D.J. Morrison, T. PrestonFormation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Gut Microbes, 7 (2016), pp. 189-200
H. Ohira, W. Tsutsui, Y. FujiokaAre short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?
J. Atheroscler. Thromb., 24 (2017), pp. 660-672
M. Sun, W. Wu, Z. Liu, et al.Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases
J. Gastroenterol., 52 (2017), pp. 1-8
E. Becker, T.S.B. Schmidt, S. Bengs, et al.Effects of oral antibiotics and isotretinoin on the murine gut microbiota
Int. J. Antimicrob. Agents, 50 (2017), pp. 342-351
A.E. Livanos, T.U. Greiner, P. Vangay, et al.Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
Nat. Microbiol., 1 (2016), p. 16140
N.B. Rutten, G.T. Rijkers, C.B. Meijssen, et al.Intestinal microbiota composition after antibiotic treatment in early life: the INCA study
BMC Pediatr., 15 (2015), p. 204
J.L. Carlson, J.M. Erickson, J.M. Hess, et al.Prebiotic dietary fiber and gut health: comparing the in vitro fermentations of beta-glucan, inulin and xylooligosaccharide
Nutrients, 9 (2017)
H.D. HolscherDietary fiber and prebiotics and the gastrointestinal microbiota
Gut Microbes, 8 (2017), pp. 172-184
C.A.M. Wegh, M.H.C. Schoterman, E.E. Vaughan, et al.The effect of fiber and prebiotics on children’s gastrointestinal disorders and microbiome
Expert Rev. Gastroenterol. Hepatol., 11 (2017), pp. 1031-1045
M. Maguire, G. MaguireThe role of microbiota, and probiotics and prebiotics in skin health
Arch. Dermatol. Res., 309 (2017), pp. 411-421
J.R. Marchesi, D.H. Adams, F. Fava, et al.The gut microbiota and host health: a new clinical frontier
Gut, 65 (2016), pp. 330-339
D. Quach, R.A. BrittonGut microbiota and bone health
Adv. Exp. Med. Biol., 1033 (2017), pp. 47-58
G. Shan, Y. Lu, B. Min, et al.A MeSH-based text mining method for identifying novel prebiotics
Medicine, 95 (2016), Article e5585
S.C. Davis, J.S. Yadav, S.D. Barrow, et al.Gut microbiome diversity influenced more by the Westernized dietary regime than the body mass index as assessed using effect size statistic
Microbiol. Open, 6 (2017)
E.C. Deehan, J. WalterThe fiber gap and the disappearing gut microbiome: implications for human nutrition
Trends Endocrinol. Metab., 27 (2016), pp. 239-242
A. Zhernakova, A. Kurilshikov, M.J. Bonder, et al.Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Science, 352 (2016), pp. 565-569
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