一项新的研究表明，发现一种名为Lipocalin-2（LCN2）的激素，能抑制小鼠进食并增加饱腹感。这种激素在人类和非人类灵长类动物身上也显示出类似的结果。这种被称为Lipocalin-2的激素有希望用以治疗天然饱腹感信号不起作用的肥胖患者。

哥伦比亚大学欧文医学中心的生理学和细胞生物物理学教授Stavroula Kousteni总结说：“我们已经证明，LCN2穿过大脑，进入下丘脑，抑制非人类灵长类动物的食物摄入。我们的研究结果表明，这种激素可以抑制食欲，毒性可以忽略不计，并为下一阶段临床应用LCN2测试打下基础。”

Hormone found to switch off hunger could help tackle obesity

Hormone found to switch off hunger could help tackle obesity: New findings suggest a hormone called Lipocalin-2 could be used as a potential treatment for obesity -- ScienceDaily

1. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. Lipocalin-2 is an anorexigenic signal in primates. eLife, 2020; 9 DOI: 10.7554/eLife.58949

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