鲜为人知的蛋白质PGRMC2似乎在肥胖和代谢疾病中起着重要作用，可能会为解决肥胖和其他潜在疾病带来新的途径。

Little-known protein appears to play important role in obesity and metabolic disease

https://www.sciencedaily.com/releases/2019/11/191120175618.htm

Journal Reference:

1. Andrea Galmozzi, Bernard P. Kok, Arthur S. Kim, J. Rafael Montenegro-Burke, Jae Y. Lee, Roberto Spreafico, Sarah Mosure, Verena Albert, Rigo Cintron-Colon, Cristina Godio, William R. Webb, Bruno Conti, Laura A. Solt, Douglas Kojetin, Christopher G. Parker, John J. Peluso, James K. Pru, Gary Siuzdak, Benjamin F. Cravatt, Enrique Saez. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature, 2019; DOI: 10.1038/s41586-019-1774-2

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衰老是由细胞代谢降低引起的吗？

在本月发表在《科学报告》上的一项研究中，筑波大学的研究人员研究了丝氨酸羟甲基转移酶2（serine hydroxymethyltransferase 2，SHMT2）基因的破坏影响细胞过程的潜在机制，如线粒体呼吸，线粒体是细胞的动力来源，释放能量为细胞活动提供能量。他们发现SHMT2表达受损导致代谢途径活性降低，而代谢途径与线粒体呼吸和细胞生长受损直接相关。发现SHMT2基因可能在代谢途径的作用中发挥作用，对于理解导致衰老的机制和与增龄相关的疾病具有重要意义。

Slowing down -- Is aging caused by decreased cellular metabolism?

https://www.sciencedaily.com/releases/2019/11/191120131336.htm

Journal Reference:

1. Haruna Tani, Takayuki Mito, Vidya Velagapudi, Kaori Ishikawa, Moe Umehara, Kazuto Nakada, Anu Suomalainen, Jun-Ichi Hayashi. Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-52372-6