基因疗法减少小鼠肥胖和逆转2型糖尿病

肥胖的流行影响了全世界近50亿人，其中许多人是儿童。肥胖相关疾病包括心脏病、中风、2型糖尿病和癌症是可预防死亡的主要原因。研究人员现在开发了一种基因疗法，专门减少肥胖小鼠的脂肪组织并逆转肥胖相关的代谢疾病。

Gene therapy reduces obesity and reverses type 2 diabetes in mice

https://www.sciencedaily.com/releases/2019/08/190829150753.htm

Journal Reference:

1. Jee Young Chung, Qurrat Ul Ain, Yoonsung Song, Seok-Beom Yong, Yong-Hee Kim. Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance. Genome Research, 2019; DOI: 10.1101/gr.246900.118

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预防阿尔茨海默病的保护因素？

研究人员发现一种叫做TREM2的蛋白质可以积极地影响阿尔茨海默病的进程。

A protective factor against Alzheimer's disease?

https://www.sciencedaily.com/releases/2019/08/190829150718.htm

Journal Reference:

1. Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease. Science Translational Medicine, 2019; 11 (507): eaav6221 DOI: 10.1126/scitranslmed.aav6221

2.