免疫治疗比化疗更能治疗侵袭性皮肤癌

Immunotherapy appears better than chemotherapy for aggressive type of skin cancer

https://www.sciencedaily.com/releases/2019/02/190207125025.htm

1. Paul Nghiem, Shailender Bhatia, Evan J. Lipson, William H. Sharfman, Ragini R. Kudchadkar, Andrew S. Brohl, Phillip A. Friedlander, Adil Daud, Harriet M. Kluger, Sunil A. Reddy, Brian C. Boulmay, Adam I. Riker, Melissa A. Burgess, Brent A. Hanks, Thomas Olencki, Kim Margolin, Lisa M. Lundgren, Abha Soni, Nirasha Ramchurren, Candice Church, Song Y. Park, Michi M. Shinohara, Bob Salim, Janis M. Taube, Steven R. Bird, Nageatte Ibrahim, Steven P. Fling, Blanca Homet Moreno, Elad Sharon, Martin A. Cheever, Suzanne L. Topalian. Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy. Journal of Clinical Oncology, 2019; JCO.18.01896 DOI: 10.1200/JCO.18.01896

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环状RNA有望成为癌症生物标志物

Circular RNA holds promise as cancer biomarker

https://www.sciencedaily.com/releases/2019/02/190207141907.htm

1. Josh N. Vo, Marcin Cieslik, Yajia Zhang, Sudhanshu Shukla, Lanbo Xiao, Yuping Zhang, Yi-Mi Wu, Saravana M. Dhanasekaran, Carl G. Engelke, Xuhong Cao, Dan R. Robinson, Alexey I. Nesvizhskii, Arul M. Chinnaiyan. The Landscape of Circular RNA in Cancer. Cell, Feb. 7, 2019; DOI: 10.1016/j.cell.2018.12.021

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癌细胞的可塑性使其难以停止

——科学家们将细胞转移时的躲避策略中的基因组、代谢过程联系起来。

研究人员已经建立了一个基本的框架，当癌细胞转移的尝试被药物或人体免疫系统阻断时，癌细胞如何适应。了解细胞的策略，有一天可以帮助科学家设计出能够控制细胞的治疗方法。

Cancer cells' plasticity makes them harder to stop

https://www.sciencedaily.com/releases/2019/02/190207173224.htm

1. Dongya Jia, Mingyang Lu, Kwang Hwa Jung, Jun Hyoung Park, Linglin Yu, José N. Onuchic, Benny Abraham Kaipparettu, Herbert Levine. Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways. Proceedings of the National Academy of Sciences, 2019; DOI: 10.1073/pnas.1816391116