在阿尔茨海默病症状出现前几年，大脑开始改变，神经元逐渐退化。德国神经退行性疾病中心（German Center for Neurodegenerative Diseases，DZNE）、赫蒂临床大脑研究所（Hertie Institute for Clinical Brain Research，HIH）和图比根大学医院（University Hospital Tuebingen）的科学家们现在表明，血液中发现的一种蛋白质可以在第一个临床症状出现之前就被用于精确监测疾病进展。这种血液标记为测试疗法提供了新的可能性。这项研究是与一个国际研究小组合作进行的，并发表在《自然医学》杂志上。

Early prediction of Alzheimer's progression: Blood protein

https://www.sciencedaily.com/releases/2019/01/190121115401.htm

1. Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, and Dominantly Inherited Alzheimer Network. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's Disease. Nature Medicine, 2019; DOI: 10.1038/s41591-018-0304-3