CRISPR/CAS9是一项新技术，它使研究人员能够精确定位和消除产生特定蛋白质所需的遗传信息。

乔治华盛顿大学（George Washington University）的研究人员首次与泰国、澳大利亚、英国和荷兰等地的研究机构的同事一起，成功地使用了基因编辑工具CRISPR/CAS9来限制导致血吸虫病和肝吸虫感染的寄生虫的影响，而血吸虫病和肝吸虫感染可导致多种人类疾病，包括胆管癌。他们的发现发表在今天的Elife杂志上的两篇论文中。

Gene-editing tool CRISPR/Cas9 shown to limit impact of certain parasitic diseases

https://www.sciencedaily.com/releases/2019/01/190115132916.htm

Journal References:

1. Wannaporn Ittiprasert, Victoria H Mann, Shannon E Karinshak, Avril Coghlan, Gabriel Rinaldi, Geetha Sankaranarayanan, Apisit Chaidee, Toshihiko Tanno, Chutima KumKhaek, Pannathee Prangtaworn, Margaret M Mentink-Kane, Christina J Cochran, Patrick Driguez, Nancy Holroyd, Alan Tracey, Rutchannee Rodpai, Bart Everts, Cornelis H Hokke, Karl F Hoffmann, Matthew Berriman, Paul J Brindley. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife, 2019; 8 DOI: 10.7554/eLife.41337

2. Patpicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo, Alex Loukas, Paul J Brindley, Thewarach Laha. Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. eLife, 2019; 8 DOI: 10.7554/eLife.41463