墨西哥城儿童终生暴露于高于当前美国标准的空气污染物浓度，包括细颗粒物（PM 2.5）。墨西哥大都市是城市极端增长和严重环境污染的一个例子，每天有数百万儿童非自愿地接触有害浓度的PM 2.5。空气污染是一个严重的公共卫生问题。发表在《阿尔茨海默病杂志》上的研究表明，暴露于空气污染物浓度达到或超过当前标准与神经炎症和阿尔茨海默病的高风险有关。

Air pollution in Mexico City is associated with the development of Alzheimer disease

https://www.sciencedaily.com/releases/2018/12/181221123805.htm

1. Lilian Calderón-Garcidueñas, Partha S. Mukherjee, Katharina Waniek, Max Holzer, Chih-kai Chao, Charles Thompson, Rubén Ruiz-Ramos, Ana Calderón-Garcidueñas, Maricela Franco-Lira, Rafael Reynoso-Robles, Angélica Gónzalez-Maciel, Ingolf Lachmann. Non-Phosphorylated Tau in Cerebrospinal Fluid is a Marker of Alzheimer’s Disease Continuum in Young Urbanites Exposed to Air Pollution. Journal of Alzheimer's Disease, 2018; 66 (4): 1437 DOI: 10.3233/JAD-180853