研究发现TPP可饿死癌细胞而又使正常细胞不受影响

More information:   Bela Ozsvari et al. Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs), Aging (2018). DOI: 10.18632/aging.101384

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TPP, or Tri-phenyl-phosphonium, is a non-toxic compound that is used as a mitochondrial targeting signal (MTC), to send attached cargo molecules to mitochondria.  Mitochondria are the powerhouse of the cells.

The Salford team, interested in TPP's behaviour as a targeting signal for mitochondria, randomly selected nine TPP-related compounds and found that five of them depleted the molecules that transfer energy in the cell.

These studies show that certain TPP compounds can distinguish between "malignant" mitochondria and "normal" mitochondria, leaving normal cells unaffected. For example, Lisanti and colleagues directly showed that these TPP molecules only killed cancer cells and cancer stem cells, while normal cells did not show any loss in viability.

Tests starve cancer cells while leaving normal cells unaffected

https://medicalxpress.com/news/2018-03-starve-cancer-cells-unaffected.html