IMMUNOTHERAPY offers huge promise, both as an addition to established therapies and as a foundation for future ones. Hundreds of trials are pairing CTLA-4, PD-1 or PD-L1 inhibitors with chemotherapy, radiation and targeted therapies. One hope is that the
September 15, 2017 To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published today in Science, researchers describe findings that certain bacteria can be found inside human pancreatic tumors. The findings further showed that some of these bacteria contain an enzyme that inactivates a common drug used to treat various cancers, including pancreatic cancer. Working with mouse models of cancer, they demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone. The research was conducted in the lab of Dr. Ravid Straussman of the Weizmann Institute of Science's Molecular