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已有 4787 次阅读 2010-12-13 13:28 |个人分类:生活点滴|系统分类:论文交流| 青蒿素, 523, 中医药

 

A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu

Authors: 

Ying LI;Yu-Lin WU;

Frontiers of Chemistry in China

Volume 5, Issue 4 (2010). Pages: 357-422

DOI: 10.1007/s11458-010-0214-5

http://journal.hep.com.cn/webpub/cipub/articledetail?articleid=2E7F80B0-E177-11DF-A3A1-9941DC162EC7&journalid=5&jyear=2010&issue=4&type=

A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Authors: 
Ying LI
1
Yu-Lin WU 2

1. Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Abstract: 
Qinghaosu (QHS) and its derivatives are a new generation of antimalarial drugs characterized by fast action, high efficacy, and good tolerance. This feature article states the discovery of QHS from traditional Chinese medicine qinghao (Artemisia annua L.) and reviews the progress during the past four decades in the research of phytochemistry of A. annua, chemical reactions and biotransformation of QHS, chemical synthesis and biosynthesis of QHS, synthesis and antimalarial activity of QHS derivatives and analogs, pharmacological studies, clinical application, and the antimalarial mechanism. Undoubtedly, QHS is an example of the value of traditional Chinese medicine in modern medicinal research.

 



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