本期【刊•见】为诸位介绍一本细胞生物学领域的期刊—Growth Factors。除了对关键指标进行详尽解读外，还向您推荐刊内近三年高被引文章，以及近一年高阅读量文章：

自体富血小板血浆与血小板裂解液用于膝骨关节炎患者的疗效对比评价

12 周高强度间歇训练与中等强度持续训练对 2 型糖尿病男性患者 FGF21、鸢尾素及肌抑素水平的影响

视神经损伤后非经典 Wnt5a 信号通路激活促炎、抗炎基因表达产生时间依赖性变化

载生长因子壳聚糖支架作为牙周组织工程生物活性仿生多功能载体：综述

Online ISSN: 1029-2292 Print ISSN: 0897-7194

Growth Factors 是一本国际跨学科期刊，刊载有关细胞增殖、分化及存活调控因子的全新研究理论与实验成果。期刊发表生长因子、细胞因子及激素相关细胞生物学、生物化学、生理学与药理学领域的研究论文、短篇通讯及综述，助力深化生物学与医学领域认知。

该期刊已被SCIE、Scopus等国际核心数据库收录。

影响因子

根据JCR显示，Growth Factors

• 在细胞生物学排名 179/207

• 在内分泌学与代谢学排名 154/198

Scopus

根据Scopus显示，Growth Factors

• 2025年CiteScore为 4.2

在生物化学、遗传学与分子生物学：

• 临床生物化学排名 65/124

• 内分泌学排名 82/132

• 细胞生物学排名 202/289

作者须知

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编辑团队

Growth Factors 的主编由彼得·麦卡勒姆癌症中心的Steven Stacker教授担任，编委覆盖澳、美、英、荷、瑞典、新西兰等多国顶尖机构专家，整体团队形成从基础分子、干细胞、生理机制、药物开发到肿瘤临床全链条跨学科评审体系，全面匹配期刊生长因子、细胞因子、激素相关多领域稿件审理需求。

主编

Steven Stacker

Steven Stacker任职于澳大利亚彼得•麦卡勒姆癌症中心，牵头肿瘤血管生成课题组，聚焦生长因子调控肿瘤血管新生、淋巴转移机制，深耕肿瘤微环境、生长因子信号通路与癌症临床转化研究，长期主导期刊整体学术方向把控。

作者分布

根据JCR显示，近三年在Growth Factors发文的国家/地区中，发文数量排名前三的有：

• 中国

• 伊朗

• 澳大利亚

近三年，在Growth Factors发文的全球高校和科研机构中，发文数量排名前三的是：

• 墨尔本大学

• 墨尔本医疗中心

• 彼得•麦卡勒姆癌症中心

近三年内高被引文章

Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis

自体富血小板血浆与血小板裂解液用于膝骨关节炎患者的疗效对比评价

作者：Sareh Hosseini et al.

文章摘要：

Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured by ELISA. All patients showed significant improvements in pain and function following treatment of KOA with PL and PRP compared to baseline. Moreover, PL's concentration of growth factors was significantly higher than PRP. A significant increase was also observed in all of the aforementioned mediators in both PRP and PL products compared to control. These results can introduce PL as a promising and alternative option for KOA therapy in the future.

The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus

12周高强度间歇训练与中等强度持续训练对 2 型糖尿病男性患者 FGF21、鸢尾素及肌抑素水平的影响

作者：Simin Riahy

文章摘要：

This study investigated the influence of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on irisin, fibroblast growth factor 21 (FGF21), and myostatin (MSTN) among men with type 2 diabetes mellitus (T2DM). Forty-five adult men with T2DM were randomly selected and assigned to receive and perform HIIT (4 × 4 min at 85–95% HRmax with three min of active rest at 50–60% HRmax in between) and MICT (walking/running continuously for 47 min at 60–70% HRmax) three sessions per week for 12 weeks, or to act as a non-exercise control (CON) group. The subjects’ blood samples were collected at baseline and 48 hours after the last intervention session. Our research revealed that both interventions resulted in similar decreases in FGF21 and MSTN when compared to the CON (p < .01). However, only the HIIT group showed a significant increase in irisin (p < .01) compared to the CON. Further, improvements in insulin resistance, body composition, and VO2 peak were noted in both intervention groups compared with those of the CON group (p < .01). It seems that while either aerobic exercise strategy could be seen as a therapy for men with T2DM, HIIT had a more advantageous effect on the irisin response.

近一年内高阅读量文章

Activation of the non-canonical Wnt5a signaling pathway following optic nerve injury induces time-dependent changes in pro- and anti-inflammatory gene expression

视神经损伤后非经典 Wnt5a 信号通路激活促炎、抗炎基因表达产生时间依赖性变化

作者：Alexander W. Venanzi et al.

文章摘要：

Optic nerve (ON) injury leads to retinal ganglion cell (RGC) degeneration and axonal atrophy. Wnt ligands are embryonic growth factors that regulate cellular differentiation and survival. We recently demonstrated that canonical and non-canonical Wnt signaling induces RGC survival and axonal regrowth after optic nerve crush (ONC) injury in mouse. Here, we investigated whether the non-canonical Wnt5a ligand induces pro-regenerative inflammation after ONC. Mice were intravitreally injected with Wnt5a or saline during ONC and retina tissue was collected for QPCR and immunofluorescence. We demonstrated that expression of arginase 1, a marker of anti-inflammatory microglia, was upregulated by Wnt5a in injured retinas, whereas iNOS, a marker of neurotoxic microglia, was suppressed. Wnt5a also induced time-dependent changes in pro-inflammatory genes Gal3, TNFα, P2RY12 and IL-6 and the anti-inflammatory gene IL-27. These results indicate that Wnt5a is an immunomodulatory ligand in the retina after ONC injury.

Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review

载生长因子壳聚糖支架作为牙周组织工程生物活性仿生多功能载体：综述

作者：Mohammed Alkandari et al.

文章摘要：

Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their design, optimization, and therapeutic potential, focusing on delivery methods, release kinetics, and biocompatibility. Studies show these scaffolds improve local delivery, sustain growth factor release, and reduce cytotoxicity while offering reinforcement and encouraging cell adhesion. Optimized release kinetics ensure a favorable prognosis, reducing the necessity for recurrent administration. Growth factor-loaded chitosan scaffolds create a biomimetic environment that supports periodontal healing, representing an innovative strategy for advancing periodontal therapy. Further research on scaffold design, growth factor combinations, and long-term outcomes is essential to refine this approach for more effective, predictable regeneration.

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