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[转载]Bacteria parallel with cancer drug reistance

已有 8084 次阅读 2014-8-29 08:20 |个人分类:SystemsBiology-系统生物学|系统分类:科研笔记|关键词:cancer,drug,resistance,,cancer,cell,non-genetic,transtion| Cell, cancer, drug, resistance, non-genetic |文章来源:转载

PLoS Biology published a paper recently about nongenetic drug resistance of bacteria “Salmonella“.

Arnoldini M, Vizcarra IA, Peña-Miller R, Stocker N, Diard M, et al. (2014) Bistable Expression of Virulence Genes in Salmonella Leads to the Formation of an Antibiotic-Tolerant Subpopulation. doi:10.1371/journal.pbio.1001928

http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001929

It is fascinating that this confluence of fitness features, nicely described here, has exact parallels in cancer cells: (i) non-genetic resistance to drugs (persistor state), (ii) slower proliferation of the persistors; (iii) inherent association of resistance with increased pathogeneicity (cancer stem cell -like properties), (iv) cooperation between non-genetically heterogeneous subpopulations (albeit more directly, via growth factors secreted by subpopuations) .

see: http://www.ncbi.nlm.nih.gov/pubmed/24045430

The key point, not emphasized here is that the non-genetic nature (absence of mutation) and population level fitness will shall make us rethink details of Darwinian evolution dynamics. Yet cancer biologists still resort to the simple mutation/selection (of individual cell) scheme to explain resistance.

One difference in cancer cells is that the slower proliferation of the tolerant state in mammalian cell is not simply the consequence of the burden of expressing the resistance conferring protein but may have deeper roots in populations and is a adaptive trait itself. But Why?.




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