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Current Biology:植物整合环境信号与BR信号根据实际环境条件塑造植株的生长

已有 483 次阅读 2020-3-5 13:43 |个人分类:每日摘要|系统分类:论文交流

SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth


First author: Moumita Srivastava; Affiliations: Durham University (杜伦大学): Durham, UK

Corresponding author: Ari Sadanandom


Brassinosteroids (BRs) play crucial roles in plant development, but little is known of mechanisms that integrate environmental cues into BR signaling. Conjugation to the small ubiquitin-like modifier (SUMO) is emerging as an important mechanism to transduce environmental cues into cellular signaling. In this study, we show that SUMOylation of BZR1, a key transcription factor of BR signaling, provides a conduit for environmental influence to modulate growth during stress. SUMOylation stabilizes BZR1 in the nucleus by inhibiting its interaction with BIN2 kinase. During salt stress, Arabidopsis plants arrest growth through deSUMOylation of BZR1 in the cytoplasm by promoting the accumulation of the BZR1 targeting SUMO protease, ULP1a. ULP1a mutants are salt tolerant and insensitive to the BR inhibitor, brassinazole. BR treatment stimulates ULP1a degradation, allowing SUMOylated BZR1 to accumulate and promote growth. This study uncovers a mechanism for integrating environmental cues into BR signaling to shape growth.




油菜素内酯(Brassinosteroids,BRs)在植物的发育过程中扮演着非常重要的角色,但是将环境信号整合到BR信号通路上的分子机制还不清楚。结合到小的类泛素修饰因子SUMO是一个大家正在逐渐认识到的将环境信号转化为细胞层面信号的重要机制。本文中,作者的研究显示一个BR信号关键转录因子BZR1的SUMO化修饰为植物在胁迫时提供一个整合环境信号以调整植物生长的渠道。SUMO化修饰能够通过抑制BZR1蛋白与BIN2酶的相互作用稳定核中的BZR1蛋白。在盐胁迫时,拟南芥植株会通过促进靶向SUMO蛋白酶ULP1a的BZR1的积累,从而使得胞质中BZR1蛋白去SUMO化修饰,停止生长。ULP1a突变体对于盐具有耐受性,并且对于BR抑制剂芸苔素唑(Brassinazole)不敏感。BR处理能够刺激ULP1a的降解,使得SUMO化的BZR1蛋白得以积累,促进生长。本文的研究揭示了一个将环境信号整合到BR信号通路上,从而调控植物生长的机制。




Highlights


  • BZR1 SUMOylation allows brassinosteroids to shape plant growth to its environment

  • BZR1蛋白的SUMO化修饰使得油菜素内酯能够根据植物所处的环境来塑造植株生长


  • SUMOylation stabilizes BZR1 by inhibiting BIN2 interaction, promoting plant growth

  • SUMO化修饰能够通过抑制BZR1蛋白与BIN2的互作来稳定BZR1蛋白,从而促进植物生长


  • Salinity stimulates BZR1 deSUMOylation via ULP1a SUMO protease to suppress growth

  • 盐分会通过SUMO蛋白酶ULP1a来刺激BZR1蛋白的去SUMO化,从而抑制生长


  • BRs destabilize ULP1a, allowing SUMOylated BZR1 to accumulate and promote growth

  • 油菜素内酯能够使得ULP1a蛋白变得不稳定,从而促进SUMO化的BZR1蛋白的积累,促进生长


通讯Ari Sadanandom (https://www.dur.ac.uk/directory/profile/?id=9384)


研究方向:病原体入侵植物以及植物感知病原体入侵的分子机制。



doi: https://doi.org/10.1016/j.cub.2020.01.089


Journal: Current Biology

Published date: February 27, 2020


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