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Nature Communications:拟南芥干细胞分裂调控因子

已有 708 次阅读 2019-12-8 17:48 |个人分类:每日摘要|系统分类:论文交流

Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks


First author: Natalie M. Clark; Affiliations: North Carolina State University (北卡罗来纳州立大学): Raleigh, US

Corresponding author: Rossangela Sozzani


Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.


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干细胞是多细胞生物形成分化细胞、组织和器官的来源,因此在细胞更新、再生及组织方面具有至关重要的作用。目前,我们已经知道了很多作用于干细胞维持、特性以及分裂等相关的干细胞特异性基因。然而,在所有干细胞类型中都有表达的基因是如何作用于干细胞调控还不清楚。本文中,作者发现在拟南芥的根组织中,一个干细胞广泛性表达基因TCX2通过调控干细胞类型特异性网络来控制干细胞的分裂。作者通过一个TCX2表达的数学模型显示了TCX2基因精确协调了不同干细胞类型的分裂。本文的结果揭示了在不同干细胞类型中都有表达的基因能够保证不同细胞之间的交叉通讯,从而确保他们能够顺利分裂,并相互协调发育。



讯:Ross Sozzani (https://cals.ncsu.edu/plant-and-microbial-biology/people/ross-sozzani/)


个人简介:2000年,意大利帕维亚大学,学士;2002年,意大利帕维亚大学,硕士;2006年,意大利帕维亚大学,博士。


研究方向:利用模式植物拟南芥的根组织研究干细胞的起始和维持。



doi: https://doi.org/10.1038/s41467-019-13132-2


Journal: Nature Communications

Published date: December 06, 2019


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