Gamete fusion is facilitated by two sperm cell-expressed DUF679 membrane proteins

First author: Philipp Cyprys; Affiliations: University of Regensburg (雷根斯堡大学): Regensburg, Germany

Corresponding author: Stefanie Sprunck 

Successful double fertilization in flowering plants relies on two coordinated gamete fusion events, but the underlying molecular processes are not well understood. We show that two sperm-specific DOMAIN OF UNKNOWN FUNCTION 679 membrane proteins (DMP8 and DMP9) facilitate gamete fusion, with a greater effect on sperm–egg fusion than on sperm–central cell fusion. We also show that sperm adhesion and sperm cell separation depend on egg cell-secreted EGG CELL 1 proteins.

开花植物的双受精是否成功依赖于两次配子融合事件，但潜在的分子机制还不清楚。本文的研究显示精细胞特异性表达的DUF679膜蛋白DMP8和DMP9能够促进配子融合，并且对于精细胞与软细胞融合的作用要比对于精细胞和中央细胞融合的作用要大。本文的研究还显示精子黏附和精细胞分离依赖于软细胞分泌蛋白EGG CELL 1。

p.s. 同期评论性文章：https://www.nature.com/articles/s41477-019-0385-0

通讯：Stefanie Sprunck (https://www.uni-regensburg.de/biologie-vorklinische-medizin/cell-biology-and-plant-biochemistry/sprunck/index.html)

研究方向：开花植物配子的形成、雌雄配子的相互作用和细胞极性的建立。

doi: https://doi.org/10.1038/s41477-019-0382-3

Journal: Nature Plants

Published date: March 08, 2019