Modulation of Asymmetric Division Diversity through Cytokinin and SPEECHLESS Regulatory Interactions in the Arabidopsis Stomatal Lineage

First author: Anne Vatén; Affiliations: Stanford University (斯坦福大学): Stanford, USA

Corresponding author: Dominique C. Bergmann

Coordinated growth of organs requires communication among cells within and between tissues. In plants, leaf growth is largely dictated by the epidermis (表皮); here, asymmetric and self-renewing divisions of the stomatal lineage create two essential cell types-pavement cells and guard cells—in proportions reflecting inputs from local, systemic, and environmental cues. The transcription factor SPEECHLESS (SPCH) is the prime regulator of divisions, but whether and how it is influenced by external cues to provide flexible development is enigmatic (令人困惑的). Here, we show that the phytohormone cytokinin (CK) can act as an endogenous signal to affect the extent and types of stomatal lineage divisions and forms a regulatory circuit with SPCH. Local domains of low CK signaling are created by SPCH-dependent cell-type-specific activity of two repressive type-A ARABIDOPSIS RESPONSE REGULATORs (ARRs), ARR16 and ARR17, and two secreted peptides, CLE9 and CLE10, which, together with SPCH, can customize epidermal cell-type composition.

植物器官的协调生长需要组织内或组织间的细胞交流。在植物中，叶片生长很大程度上受限于表皮的发育，气孔细胞的不对称和自我更新分裂创造了两个细胞类型：扁平细胞和保卫细胞，部分反映了局部、系统和环境的输入信号。转录因子SPCH是控制分裂的主要调控子，但其是如何被外部环境信号所影响以保证叶片表皮动态发育的具体情况还不清楚。本文的研究结果显示细胞激素细胞分裂素CK可以作为内源性信号影响气孔细胞分裂的程度和类型，并和SPCH一起形成一个调控回路。局部区域的低CK信号是由两个抑制因子ARR16和ARR17的SPCH依赖型细胞类型特异性活性和两个能与SPCH一起控制表皮细胞类型组成的分泌多肽CLE9和CLE10共同所创造的。

通讯：Dominique C. Bergmann（https://profiles.stanford.edu/dominique-bergmann）

个人简介：2000年，科罗拉多大学，分子生物学博士；Carnegie研究所，植物发育博士后。

研究方向：拟南芥气孔发育中的细胞不对称分裂。

doi: https://doi.org/10.1111/tpj.14102

Journal: Developmental Cell

Published date: 06 September, 2018

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