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Nature Plants:FRIGIDA作用于拟南芥开花调控

已有 5737 次阅读 2018-9-23 10:13 |个人分类:每日摘要|系统分类:论文交流


FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production


First author: Zicong Li; Affiliations: CAS Center for Excellence in Molecular Plant Sciences (中科院分子植物科学卓越创新中心): Shanghai, China

Corresponding author: Yuehui He (何跃辉)


FRIGIDA (FRI) upregulates the expression of the potent floral repressor FLOWERING LOCUS C (FLC) to confer the winter-annual growth habit in Arabidopsis thaliana: accelerated transition to flowering after prolonged (持续很久的) cold exposure (vernalization). Here, we show that FRI, histone acetyltransferases (组蛋白酰基转移酶), the histone methyltransferase COMPASS-like and other chromatin modifiers are part of a FRI-containing supercomplex enriched in a region around the FLC transcription start site (TSS) to promote its expression. Several FRI partners are also enriched in a 3’ region flanking FLC and, together with FRI, they function to increase the frequency of physical association of the region around TSS with the 3’ region and promote the expression of both sense FLC and antisense non-coding RNAs. Our results show that the FRI supercomplex establishes a local chromosomal environment at FLC with active chromatin modifications and topology to promote transcriptional activation, fast elongation and efficient pre-messenger RNA splicing, leading to a high-level production of FLC mRNAs.




FRI通过上调开花抑制因子FLC的表达来赋予拟南芥冬季-年生长的特性:促进拟南芥在长时间的春化,即冷处理之后向开花期的转变。本文的研究显示FRI、组蛋白酰基转移酶、组蛋白甲基转移酶类COMPASS和一些其它的染色质修饰因子作为含有FRI的超级复合物的一部分,在FLC转录起始位点附近区域富集,促进FLC的表达。一些FRI的伴侣基因也在FLC的3’侧翼区域富集,与FRI一起共同增加了TSS附近区域和3’区域的物理联系频率,同时促进有义FLC和反义非编码RNA的表达。本文的研究结果显示FRI超级复合物通过在FLC所在区域建立起了一个区域化的、带有激活态的染色质修饰和拓扑结构的染色质环境,促进了FLC的转录激活,快速伸长及高效前提信使RNA剪切,从而形成了最终的FLC mRNA高水平产量。



通讯何跃辉http://sourcedb.sibs.cas.cn/zw/rck/201507/t20150714_4393186.html


个人简介:1997-2001年,美国肯塔基大学,植物生理学博士;2001-2005年,美国威斯康星大学麦迪逊分校,博士后。


研究方向植物花期调控的分子与表观遗传机理,植物发育表观遗传学。



doi: https://doi.org/10.1038/s41477-018-0250-6


Journal: Nature Plants

Published date: 17 September, 2018


(P.S. 原文下载:链接:https://pan.baidu.com/s/1qFiSsqwlF_7JjmGMbedfhQ  密码:dmu6)




https://blog.sciencenet.cn/blog-3158122-1136496.html

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