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患湿疹孩子1岁内的肠道微生物变化

已有 1710 次阅读 2017-5-19 09:13 |个人分类:菌群|系统分类:科研笔记| 母婴

文章:Low diversity of the gut microbiota in infants with atopiceczema

时间:2011


研究目的:We have used barcoded16S rRNA 454-pyrosequencing to assess the microbial diversity and characterize the dominant bacteria in stool during the first year of life in infants who either had atopic eczema or did nothave any allergic manifestation up to 2 years of age.

研究样本:In this study the infants received probiotics or placebo daily from day 1 to 3 until 12 months of age.

Among the 188 infants completing the original study and from whom stool samples were available from all 3 sampling occasions, 20 infants with atopic eczema and 20 without any allergic manifestation were randomly selected for this study.

研究结果:

1) Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P =.004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P =.02 and P =.01) and the phylum Proteobacteria at 12 months of age (P 5 .02).

2) The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability.

3) At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation.



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