文章：Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life

时间：2017

文章目的： In our present work, a longitudinal study was conducted to describe the colonization and succession of the three domains of life within the GIT of newborns. More specifically, we investigated the microbiome changes during the first year of life among eight vaginally delivered (VD) infants and seven infants delivered by C-section (CSD).

研究样本：Fecal samples were scheduled to be collected at day 1, 3, 5, 28, 150 and 365. SIxty-five fecal samples were collected between September 2012 and April 2014 at the CHL from eight healthy VD and seven healthy CSD infants at six time points (samples collected aroud days 1, 3, 5, 28, 150, and 365).

研究结果：

1）菌群丰度；

2）多样性比较；

3）基于距离的pcoa分析；

4）F/B的比值变化；

5）一些特定菌的分析。

总结：

1）研究切入点蛮好

2）数据样本量稍微少一些；

3）图表和分析感觉没深入。