博文
【读书笔记】Genetics: from genes to genomes
||
本书从基因组的角度介绍了生命过程的原理和变化方式。内容上描述细致、插图丰富，结构上安排严谨，感觉同《Molecular Biology of the Cell》的水平相当，并且多了很多新进展的讨论（例如：RNAi）。书中前面几章由孟德尔的实验出发，引入染色体的概念，然后关注到基因、基因组、核酸和核酸测序的方法。中间几章逐渐展开讨论分子水平的各种变化对生物性状的影响，和在细胞分裂过程中基因组上的各种错误所产生的结果。最后，将单细胞的分析延伸到多细胞以至于整个族群上面，并重点讨论了进化和免疫系统的运作。全书以染色体为主线，将细胞中各种繁杂、细微的调控关系娓娓道来，在很多地方将讨论延伸到了癌症和其他疾病的发生机理上，加深了读者的印象。推荐对“基因”感兴趣的读者阅读。
网络资源：
官方主页，课件习题
观点摘录：
Page 9:
The goal of understanding higher-order processes that arise from interacting networks of genes, proteins, cells, and organs is one of the most challenging aspects of modern biology.
Page 19:
In short, Mendel purposely set up a simplified "black-and-white" experimental system and then figured out how it worked. He did not look at the vast number of variables that determine the development of a prize ram nor at the origin of differences between species. Rather, he looked at discrete traits that came in two mutually exclusive forms and asked questions that could be answered by observation and computation.
Page 710:
A cell requires many mutations to become cancerous. Exposure to environmental mutagens probably generates most of these mutations.
Page 793:
The AIDS virus (HIV) is a worthy adversary for the human immune system because it is able to diversify and amplify via selection far faster than the immune response itself.
Page 801:
Although these comparative evolutionary studies are preliminary and incomplete, they suggest that a subtle rewiring of a gene regulatory network and the joining together of elements from previously separate sub-networks can encode enormous phenotypic changes, including those that give rise to sea urchin versus starfish bogy plans.
图书信息：
图书目录：
1 Genetics: The Study of Biological Information 1
2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity 13
3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype 45
4 The Chromosome Theory of Inheritance 81
5 Linkage, Recombination, and the Mapping of Genes on Chromosomes 123
6 DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information 167
7 Anatomy and Function of a Gene: Dissection Through Mutation 207
8 Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein 255
9 Deconstructing the Genome: DNA at High Resolution 301
10 Reconstructing the Genome Through Genetic and Molecular Analysis 351
11 The Direct Detection of Genotype Distinguishes Individual Genomes 391
12 Systems Biology and Proteomics 437
13 The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA 465
14 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes 489
15 The Prokaryotic Chromosome: Genetic Analysis in Bacteria 539
16 The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance 581
17 Gene Regulation in Prokaryotes 609
18 Gene Regulation in Eukaryotes 643
19 Cell-Cycle Regulation and the Genetics of Cancer 685
20 Using Genetics to Study Development 717
21 The Genetic Analysis of Populations and How They Evolve 757
22 Evolution at the Molecular Level 791
https://blog.sciencenet.cn/blog-286702-608493.html
上一篇：【读书笔记】Probabilistic methods for bioinformatics with
下一篇：【读书笔记】Chaos and Fractals: New frontiers of Science
网络资源：
官方主页，课件习题
观点摘录：
Page 9:
The goal of understanding higher-order processes that arise from interacting networks of genes, proteins, cells, and organs is one of the most challenging aspects of modern biology.
Page 19:
In short, Mendel purposely set up a simplified "black-and-white" experimental system and then figured out how it worked. He did not look at the vast number of variables that determine the development of a prize ram nor at the origin of differences between species. Rather, he looked at discrete traits that came in two mutually exclusive forms and asked questions that could be answered by observation and computation.
Page 710:
A cell requires many mutations to become cancerous. Exposure to environmental mutagens probably generates most of these mutations.
Page 793:
The AIDS virus (HIV) is a worthy adversary for the human immune system because it is able to diversify and amplify via selection far faster than the immune response itself.
Page 801:
Although these comparative evolutionary studies are preliminary and incomplete, they suggest that a subtle rewiring of a gene regulatory network and the joining together of elements from previously separate sub-networks can encode enormous phenotypic changes, including those that give rise to sea urchin versus starfish bogy plans.
图书信息：
| Title | Genetics : from genes to genomes / Leland H. Hartwell ... [et al.]. |
| Publisher | Boston : McGraw-Hill Higher Education, c2008. |
| Edition | 3rd ed. |
图书目录：
1 Genetics: The Study of Biological Information 1
2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity 13
3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype 45
4 The Chromosome Theory of Inheritance 81
5 Linkage, Recombination, and the Mapping of Genes on Chromosomes 123
6 DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information 167
7 Anatomy and Function of a Gene: Dissection Through Mutation 207
8 Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein 255
9 Deconstructing the Genome: DNA at High Resolution 301
10 Reconstructing the Genome Through Genetic and Molecular Analysis 351
11 The Direct Detection of Genotype Distinguishes Individual Genomes 391
12 Systems Biology and Proteomics 437
13 The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA 465
14 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes 489
15 The Prokaryotic Chromosome: Genetic Analysis in Bacteria 539
16 The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance 581
17 Gene Regulation in Prokaryotes 609
18 Gene Regulation in Eukaryotes 643
19 Cell-Cycle Regulation and the Genetics of Cancer 685
20 Using Genetics to Study Development 717
21 The Genetic Analysis of Populations and How They Evolve 757
22 Evolution at the Molecular Level 791
https://blog.sciencenet.cn/blog-286702-608493.html
上一篇：【读书笔记】Probabilistic methods for bioinformatics with
下一篇：【读书笔记】Chaos and Fractals: New frontiers of Science
