AIMS: There is still no effective way to save asurvivinghealthymindwhen there is critical organ failure in the body. The next frontier in CTA is allo-head and body reconstruction (AHBR), and just asanimalmodelswere key in the development of CTA, they will be crucial in establishing theproceduresof AHBR for clinical translation. METHODS AND RESULTS: Our approach, pioneered inmice, involves retaining thedonorbrain stemandtransplantingtherecipienthead. Our preliminary data inmicesupport that this allows for retention of breathing and circulatory function. Critical aspects of the current protocol include avoidingcerebralischemiathrough cross-circulation (donorto recipient) and retaining thedonorbrain stem. Successful clinical translation of AHBR will become a milestone ofmedicalhistoryand potentially could save millions of people. CONCLUSIONS: This experimental study has confirmed a method to avoidcerebralischemiaduring thesurgeryand solved an important part of the problem of how to accomplish long-termsurvivalafter transplantation and preservation of thedonorbrain stem.
Affiliation:Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University,Harbin,China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University,Harbin,China; Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago,Chicago,IL,USA..
In 1970, the first cephalosomatic linkage was achieved in themonkey. However, thetechnologydid not exist for reconnecting thespinal cord, and this line of research was no longer pursued. In this paper, an outline for the first total cephalic exchange in man is provided and spinal reconnection is described. The use of fusogens,specialmembrane-fusion substances, is discussed in view of the first human cord linkage. Several human diseases without cure might benefit from theprocedure.
CONCLUSIONS: This experimental study has confirmed a method to avoidcerebralischemiaduring thesurgeryand solved an important part of the problem of how to accomplish long-termsurvivalafter transplantation and preservation of thedonorbrain stem.
Affiliation:Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University,Harbin,China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University,Harbin,China; Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago,Chicago,IL,USA..
Tissue-engineered approach for the treatment of steroid-inducedosteonecrosisof the femoral head:transplantationofautologousmesenchymalstemcellsculturedwith beta-tricalciumphosphateceramicsandfreevascularizedfibula.
Autologousmesenchymalstemcells(MSCs)culturedwith beta-tricalciumphosphate(beta-TCP)ceramicsand with afreevascularizedfibulawere transplanted into threepatientswith steroid-inducedosteonecrosisof the femoral head.
Studies on the effects ofdecapitation,head transplantationandecdysonetherapy on the ultrastructural organization of the midgut in 5th-instarlarvaeofRhodniusprolixus, were carried out.
Affiliation:Department of Biochemistry and Molecular Biology, Fundação Oswaldo Cruz, Av. Brasil 4365, Castel Mourisco-5o Andar, Manguinhos, CEP 21045-900, RiodeJaneiro,Brazil.
Studies on the effects ofdecapitation,head transplantation, azadirachtin, andecdysonetherapy on the ultrastructural organization of the midgut ofRhodniusprolixus, a vector of the protozoanTrypanosomacruzi, show a distinct effect on the organization of theepithelial cells.
Affiliation:Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense, Morro do Valonguinho SIN degrees,Niterói, RJ, CEP 24001-970,Brazil..
Journal:The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transpl),Vol. 17 (12): 1184-94, 1998.
CONCLUSIONS: By diluting inflammatory mediators,apheresisleads to a rapid improvement in cardiac function during severehumoralrejection afterhead transplantation.
From 1978 to 1989, we carried out 15 resections of singlevertebralbodies, with homologous femoralhead transplantation, for malignant and benign lesions of the spine.
