GLYPHOSATE ISOPROPYLAMINE SALT
CASRN: 38641-94-0 ISOPROPYLAMINE盐草甘膦 |  |
FULL RECORD DISPLAY
Displays all fields in the record. For other data, click on the Table of ContentsSubstance Identification:Substance Name:GLYPHOSATE ISOPROPYLAMINE SALT
ISOPROPYLAMINE盐草甘膦CAS Registry Number:
38641-94-0Major Use:
PESTICIDES (HERBICIDES)
Data Type:
Carcinogenicity
Mutagenicity
Studies Data:Carcinogenicity Studies: 致癌研究
| Species: | Rat |
| Strain/Sex: | Sprague-Dawley/Male (50/Group) |
| Route: | Oral 口腔 |
| Dose: | 0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo |
| Results: | Negative 阴性 |
| Reference: | |
[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]
| Species: | Rat |
| Strain/Sex: | Sprague-Dawley/Female (50/Group) |
| Route: | Oral |
| Dose: | 0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo |
| Tumor Site/ Type of Lesion: | Adrenal cortex: carcinoma (3/50 in high dose group vs 0 in all other groups) |
| Results: | Positive. (Department of Pesticides Regulation reviewer describes as a possible adverse effect.) 阳性 |
| Reference: | |
[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]
Mutagenicity Studies:
| Test System: | AMES SALMONELLA TYPHIMURIUM |
| Strain Indicator: | TA98 |
| Metabolic Activation: | S-9, AROCLOR 1254 |
| Method: | STANDARD PLATE |
| Dose: | 180-1440 UG/PLATE |
| Results: | NEGATIVE 阴性 |
| Reference: | |
[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]
| Test System: | AMES SALMONELLA TYPHIMURIUM |
| Strain Indicator: | TA100 |
| Metabolic Activation: | NONE |
| Method: | STANDARD PLATE |
| Dose: | 180-1440 UG/PLATE |
| Results: | NEGATIVE 阴性 |
| Reference: | |
[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]
| Test System: | AMES SALMONELLA TYPHIMURIUM |
| Strain Indicator: | TA100 |
| Metabolic Activation: | S-9, AROCLOR 1254 |
| Method: | STANDARD PLATE |
| Dose: | 180-1440 UG/PLATE |
| Results: | POSITIVE 阳性 |
| Reference: | |
[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]
| Test System: | BONE MARROW POLYCHROMATIC ERYTHROCYTES |
| End Point: | IN VIVO MICRONUCLEUS |
| Species: | MOUSE |
| Strain/Sex: | SWISS/MALE, FEMALE |
| Route: | IP 2X IN AQUEOUS SUSPENSION WITHIN 24 HR |
| Dose: | 50.0-200.0 MG/KG |
| Dose Regimen: | 48 HR TREATMENT |
| Results: | NEGATIVE 阴性 |
| Reference: | |
[GRISOLIA,CK; A COMPARISON BETWEEN MOUSE AND FISH MICRONUCLEUS TEST USING CYCLOPHOSPHAMIDE, MITOMYCIN C AND VARIOUS PESTICIDES; MUTAT. RES. 518(2): 145-150, 2002]
| Test System: | BOVINE LYMPHOCYTES |
| End Point: | IN VITRO MICRONUCLEUS |
| Metabolic Activation: | NONE |
| Dose: | 28; 56; 140; 280; 560 UM/L (TEST MATERIAL SOLVENT: WATER) |
| Dose Regimen: | 24 OR 48 HR CONTINUOUS TREATMENT |
| Results: | NEGATIVE 阴性 |
| Reference: | |
[PIESOVA,E; THE INFLUENCE OF DIFFERENT TREATMENT LENGHT ON THE INDUCTION OF MICRONUCLEI IN BOVINE LYMPHOCYTES AFTER THE EXPOSURE OF GLYPHOSATE; FOLIA VET. 48(3):130-134, 2004]
Administrative Information:CCRIS Record Number:6431
Last Revision Date:20110526
Update History:
Complete Update on 2011-05-26
Complete Update on 2006-02-02
Complete Update on 2005-09-01
Complete Update on 04/07/1995, 7 fields added/edited/deleted.
