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鱼和不饱和脂肪酸与乳腺癌风险研究的知识发现
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科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546
A-query: fish and marine n-3 polyunsaturated fatt...
C-query: breast cancer
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 5 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 25831 and can be accessed from the start page after you leave this session. There are 544 terms on the current B-list (102 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.
To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.
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A query = fish and marine n-3 polyunsaturated fatty acids started Mon Dec 1 20:05:22 2014
A query resulted in 421 titles
C_query_raw: breast cancer Mon Dec 1 20:05:40 2014
C: breast cancer 290025
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C_query_raw: breast cancer Mon Dec 1 20:05:43 2014
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Concepts & Ideas
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1 women health initiative
2 prostate cancer risk
3 n-3 fatty acid
4 expression analysis
5 inflammatory cytokine
6 n-3 polyunsaturated
7 based cohort study
8 n-3
9 n-3 polyunsaturated fatty
10 mineral density risk
11 n-6
12 endometrial cancer risk
13 n-3 pufa
14 population based cohort
15 cancer risk
16 induced mammary tumorigenesis
17 anthracene induced mammary
18 inflammatory marker
19 systematic review meta
20 inhibit proliferation
21 mammary adenocarcinoma cell
22 inflammatory cytokine gene
23 health initiative
24 n-6 fatty acid
25 registry based
26 pre postmenopausal
27 long chain n-3
28 mammary tumorigenesis
29 organochlorine
30 pro inflammatory cytokine
31 persistent organic pollutant
32 postmenopausal
33 review meta analysis
34 bone mineral density
35 postmenopausal women
36 reduction visceral adipose
37 dietary n-3
38 meta analysis
39 cardiovascular risk
40 acid inhibit proliferation
41 biomarker
42 homocysteine level
43 inhibit proliferation human
44 cardiovascular health study
45 control study
46 plasma homocysteine level
47 risk diabetes
48 mitochondrial biogenesis
49 mammary adenocarcinoma
50 population based
51 cohort study
52 health outcome
53 term survival
54 patient inflammatory
55 acute coronary syndrome
56 risk marker
57 risk factor
58 time trend
59 heart rate variability
60 expression methylation
61 randomized controlled
62 endometrial
63 japanese women
64 cardiovascular event
65 registry
66 cardiac autonomic
67 randomised controlled trial
68 colorectal
69 proliferation human
70 clinical outcome
71 randomised controlled
72 antioxidant level
73 blind placebo controlled
74 dietary n-3 fatty
75 alpha production macrophage
76 end stage renal
77 expression pro inflammatory
78 conjugated linoleic acid
79 expression a
80 systematic review
81 expression prostaglandin
82 mouse model
83 newly diagnosed
84 sustainability
85 placebo controlled trial
86 oxidative
87 double blind placebo
88 beta gene
89 pro inflammatory
90 beta oxidation
91 control trial
92 stage renal disease
93 cancer post
94 risk cardiovascular
95 desaturase expression
96 risk uterine
97 mitochondrial
98 clinical trial
99 randomised double blind
100 promoter different
101 chinese
102 resonance
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies.
1Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China.
To investigate the association between intake of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of breast cancer and to evaluate the potential dose-response relation.
DESIGN:Meta-analysis and systematic review of prospective cohort studies.
DATA SOURCES:PubMed and Embase up to December 2012 and references of retrieved relevant articles.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES:Prospective cohort studies with relative risk and 95% confidence intervals for breast cancer according to fish intake, n-3 PUFA intake, or tissue biomarkers.
RESULTS:Twenty six publications, including 20,905 cases of breast cancer and 883,585 participants from 21 independent prospective cohort studies were eligible. Eleven articles (13,323 breast cancer events and 687,770 participants) investigated fish intake, 17 articles investigated marine n-3 PUFA (16,178 breast cancer events and 527,392 participants), and 12 articles investigated alpha linolenic acid (14,284 breast cancer events and 405,592 participants). Marine n-3 PUFA was associated with 14% reduction of risk of breast cancer (relative risk for highest v lowest category 0.86 (95% confidence interval 0.78 to 0.94), I(2)=54), and the relative risk remained similar whether marine n-3 PUFA was measured as dietary intake (0.85, 0.76 to 0.96, I(2)=67%) or as tissue biomarkers (0.86, 0.71 to 1.03, I(2)=8%). Subgroup analyses also indicated that the inverse association between marine n-3 PUFA and risk was more evident in studies that did not adjust for body mass index (BMI) (0.74, 0.64 to 0.86, I(2)=0) than in studies that did adjust for BMI (0.90, 0.80 to 1.01, I(2)=63.2%). Dose-response analysis indicated that risk of breast cancer was reduced by 5% per 0.1g/day (0.95, 0.90 to 1.00, I(2)=52%) or 0.1% energy/day (0.95, 0.90 to 1.00, I(2)=79%) increment of dietary marine n-3 PUFA intake. No significant association was observed for fish intake or exposure to alpha linolenic acid.
CONCLUSIONS:Higher consumption of dietary marine n-3 PUFA is associated with a lower risk of breast cancer. The associations of fish and alpha linolenic acid intake with risk warrant further investigation of prospective cohort studies. These findings could have public health implications with regard to prevention of breast cancer through dietary and lifestyle interventions.
Dietary fats and breast cancer risk. [BMJ. 2013]
| fish and marine n-3 polyunsatu... | systematic review meta | breast cancer |
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