博文
胸腺瘤基因的知识发现
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科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
研究进展
胸腺瘤（Thymoma）是一种比较罕见的癌症。日前科学家们发现，仅凭一个基因就可以区分胸腺瘤的侵袭性。快速生长的胸腺瘤需要高强度的治疗，而生长缓慢的胸腺瘤不需要进行这样的处理。生物通 www.ebiotrade.com
胸腺瘤是一种起源于胸腺上皮细胞的癌症。胸腺是淋巴系统的关键器官，被称为“杀手”的T细胞就在那里成熟。虽然还不清楚GTF2l基因突变在人类肿瘤中的具体作用，但Lombardi综合癌症中心和美国国家癌症研究所的科学家们发现，几乎所有的惰性胸腺瘤（生长缓慢，不具侵袭性）都带有这一突变。这项研究发表六月二十九日的Nature Genetics杂志上。
http://www.ebiotrade.com/newsf/read.asp?page=2014630162842730
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
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| A-query: GTF2I C-query: Thymoma The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 0 articles appeared in both literatures. The results of this search are saved under id # 6698 and can be accessed from the start page after you leave this session. There are 81 terms on the current B-list (24 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. |
job id # 6698 started Tue Jul 1 00:29:08 2014
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: ThymomaTue Jul 1 00:29:40 2014
A query = Thymoma started Tue Jul 1 00:29:41 2014
A query resulted in 8764 titles
C_query_raw: Thymoma Tue Jul 1 00:30:04 2014
C: Thymoma 8764
A: pubmed_query_A 8764
AC: ( Thymoma ) AND ( Thymoma ) 8764
A_query_raw: GTF2ITue Jul 1 00:30:09 2014
A query = GTF2I started Tue Jul 1 00:30:10 2014
A query resulted in 111 titles
C_query_raw: GTF2I Tue Jul 1 00:30:13 2014
C: GTF2I 111
A: pubmed_query_A 111
AC: ( GTF2I ) AND ( GTF2I ) 111
C_query_raw: GTF2I Tue Jul 1 00:30:19 2014
C: GTF2I 111
A: pubmed_query_A 111
AC: ( GTF2I ) AND ( GTF2I ) 111
C_query_raw: Tue Jul 1 00:30:29 2014
C:
A: pubmed_query_A 111
AC: ( GTF2I ) AND ( ) 111
C_query_raw: GTF2I Tue Jul 1 00:30:40 2014
C: GTF2I 111
A: pubmed_query_A 111
AC: ( GTF2I ) AND ( GTF2I ) 111
C_query_raw: Thymoma Tue Jul 1 00:31:04 2014
C: Thymoma 8764
A: pubmed_query_A 111
AC: ( GTF2I ) AND ( Thymoma ) 0
C query = Thymoma started Tue Jul 1 00:31:05 2014
C query resulted in 8764 titles
A AND C query resulted in 0 titles
506 B-terms ready on Tue Jul 1 00:33:10 2014
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
81 B-terms left after filter executed Tue Jul 1 00:33:44 2014
B-list on Tue Jul 1 00:34:56 2014
1 akt
2 pi3k
3 signal regulated kinase
4 transcription factor
5 grp78
6 tyrosine kinase
7 tgf beta
8 brca1
9 p53
10 i gene
11 snp
12 isoform
13 chain gene
14 protein kinase
15 promoter
16 dna binding
17 genome wide
18 promoter activity
19 ras
20 estrogen receptor alpha
21 enhancer
22 genomic
23 gene associated
24 domain
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=6698
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