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Sci Transl Med Table of Contents for 28 May 2014

已有 1745 次阅读 2014-5-29 07:42 |个人分类:转化医学|系统分类:科研笔记|关键词:学者


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Table of Contents
 
28 MAY 2014VOLUME 6, ISSUE 238

Join Science Translational Medicine in Beijing, China, Oct 13-15, 2014 for our inaugural Bridging Biomedical Worlds conference "Turning Obstacles into Opportunities for Stem Cell Therapy".


In this week's issue:

RESEARCH ARTICLES

REGENERATIVE MEDICINE

Low-power laser–activated endogenous latent transforming growth factor–β1 (LTGF-β1) directs resident dental stem cell differentiation to promote dentin regeneration.


CANCER

CTLA-4 blockade induces T cell repertoire turnover, but high-frequency clonotypes are maintained in patients with favorable outcomes.


CANCER

The cell of origin for the chronic lymphoproliferative disorder hairy cell leukemia is a long-term hematopoietic stem cell, as shown through human genetic data and murine genetic models.


HUMAN IMMUNOLOGY

Umbilical cord blood from healthy neonates with no known infectious exposure contains T cells with an effector memory–like phenotype.


EDITORIAL

INNOVATION

Convergent science will require human diversity—individuals with different backgrounds and life experiences—to drive it forward.


FOCUS

CANCER GENOMICS

Unearthing of the BRAF mutation in hematopoietic stem cells reveals an unexpected origin for a mature B cell malignancy and a new therapeutic target.



EDITORS' CHOICE

ANTIBIOTICS

Damaging reactive oxygen species drives antibiotic-mediated killing.


KIDNEY DISEASE

Angiotensin receptor suppression in macrophages infiltrating damaged kidneys exacerbates renal fibrosis.


SEPSIS

Alteration of the neonatal gut microbiome with antibiotics can impair neutrophil function and increase susceptibility to bacterial sepsis.


LEARNING AND MEMORY

Blood from young mice counteracts age-related deterioration of learning and memory in old mice.


 
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