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帕金森病基因治疗研究进展与信息分析报告

已有 2396 次阅读 2014-1-13 16:20 |个人分类:信息分析|系统分类:科研笔记

《柳叶刀》（The Lancet）杂志上一项1/2期临床试验的结果，通过一种叫做ProSavin的新型三重基因疗法重编程脑细胞生成多巴胺，有可能安全地改善帕金森病患者的运动功能。生物通 www.ebiotrade.com

研究的领导者Stéphane Palfi教授说：“多巴胺缺乏会导致震颤、肢体僵硬，以及帕金森病特征性的平衡丧失。”

“ProSavin利用了一种无活力的病毒，将三个多巴胺生成基因直接传递到控制运动的大脑纹状体区域，以期将非多巴胺生成纹状体神经元转变为多巴胺生成工厂，替代帕金森病中丧失的多巴胺源。”生物通 www.ebiotrade.com

帕金森病是仅次于阿尔茨海默氏症，居第二位的最常见神经退行性疾病，全球有大约500万人受累于这一疾病。负责控制运动的大脑区域丧失多巴胺生成神经细胞导致了帕金森病症状的出现。

http://www.ebiotrade.com/newsf/read.asp?page=2014110163707654

分析平台 http://www.pubmedplus.cn/

检索策略 gene therapy and Parkinson's disease

分析结果如下

筛选或者

字段：副主题词搭配

记录数

占%

01.Parkinson Disease/therapy 1100 篇49.460%

02.Parkinson Disease/etiology 621 篇27.923%

03.Parkinsonian Disorders/drug therapy 568 篇25.540%

04.Parkinsonian Disorders/genetics 565 篇25.405%

05.Neurodegenerative Diseases/genetics 553 篇24.865%

06.Neurodegenerative Diseases/drug therapy 536 篇24.101%

07.Parkinson Disease/genetics 489 篇21.987%

08.Brain/metabolism 462 篇20.773%

09.Parkinson Disease/drug therapy 456 篇20.504%

10.Dopamine/physiology 391 篇17.581%

11.Neurons/physiology 380 篇17.086%

12.Neurodegenerative Diseases/metabolism 376 篇16.906%

13.Nerve Tissue Proteins/genetics 372 篇16.727%

14.Dopamine/metabolism 337 篇15.153%

15.Parkinson Disease/metabolism 311 篇13.984%

16.Genetic Therapy/methods 302 篇13.579%

17.Nerve Tissue Proteins/metabolism 296 篇13.309%

18.Neurons/metabolism 291 篇13.085%

19.Brain/pathology 281 篇12.635%

20.Neurodegenerative Diseases/pathology 272 篇12.230%

21.Neurons/cytology 249 篇11.196%

22.Parkinson Disease/pathology 229 篇10.297%

23.Antiparkinson Agents/therapeutic use 218 篇9.802%

24.Levodopa/therapeutic use 217 篇9.757%

25.Parkinson Disease/physiopathology 205 篇9.218%

26.Tyrosine 3-Monooxygenase/metabolism 194 篇8.723%

27.Corpus Striatum/metabolism 182 篇8.183%

28.Neurons/drug effects 169 篇7.599%

29.Antiparkinson Agents/pharmacology 157 篇7.059%

30.Gene Expression Regulation/drug effects 153 篇6.879%

31.Neurons/pathology 148 篇6.655%

32.Substantia Nigra/metabolism 148 篇6.655%

33.Neuroprotective Agents/therapeutic use 143 篇6.430%

34.Tyrosine 3-Monooxygenase/genetics 128 篇5.755%

35.Neuroprotective Agents/pharmacology 118 篇5.306%

36.Corpus Striatum/drug effects 118 篇5.306%

37.Dependovirus/genetics 118 篇5.306%

38.Substantia Nigra/pathology 117 篇5.261%

39.RNA, Messenger/metabolism 94 篇4.227%

40.Levodopa/adverse effects 84 篇3.777%

41.alpha-Synuclein/genetics 77 篇3.462%

42.Parkinson Disease/complications 70 篇3.147%

43.alpha-Synuclein/metabolism 58 篇2.608%

44.Parkinson Disease/enzymology 58 篇2.608%

45.Mitochondria/metabolism 43 篇1.933%

46.Apoptosis/drug effects 43 篇1.933%

47.Reactive Oxygen Species/metabolism 40 篇1.799%

48.Oxidative Stress/physiology 37 篇

1.664

筛选或者

字段：主题词与主题词

记录数

占%

01.主题词中同时含有"brain"与"parkinson disease" 32 篇23.881%

02.主题词中同时含有"brain"与"neurons" 25 篇18.657%

03.主题词中同时含有"neurons"与"parkinson disease" 21 篇15.672%

04.主题词中同时含有"cell differentiation"与"stem cells" 19 篇14.179%

05.主题词中同时含有"neurons"与"stem cells" 14 篇10.448%

06.主题词中同时含有"cell differentiation"与"neurons" 13 篇9.701%

07.主题词中同时含有"mesencephalon"与"neurons" 13 篇9.701%

08.主题词中同时含有"mesencephalon"与"parkinson disease" 11 篇8.209%

09.主题词中同时含有"gene expression regulation"与"neurons" 9 篇6.716%

10.主题词中同时含有"corpus striatum"与"neurons" 9 篇6.716%

11.主题词中同时含有"behavior, animal"与"neurons" 8 篇5.970%

12.主题词中同时含有"neurons"与"rna, messenger" 7 篇5.224%

13.主题词中同时含有"levodopa"与"parkinson disease" 6 篇4.478%

14.主题词中同时含有"dependovirus"与"genetic vectors" 6 篇4.478%

15.主题词中同时含有"neurons"与"substantia nigra" 5 篇3.731%

16.主题词中同时含有"bone marrow cells"与"cell differentiation" 5 篇3.731%

17.主题词中同时含有"bone marrow cells"与"stromal cells" 5 篇3.731%

18.主题词中同时含有"cell survival"与"gene expression regulation" 4 篇2.985%

19.主题词中同时含有"green fluorescent proteins"与"neurons" 4 篇2.985%

20.主题词中同时含有"nerve degeneration"与"parkinson disease" 4 篇2.985%

21.主题词中同时含有"adenoviridae"与"genetic vectors" 4 篇2.985%

22.主题词中同时含有"corpus striatum"与"substantia nigra" 4 篇2.985%

23.主题词中同时含有"apoptosis"与"cell survival" 3 篇2.239%

24.主题词中同时含有"antioxidants"与"neuroprotective agents" 3 篇2.239%

25.主题词中同时含有"behavior, animal"与"motor activity" 3 篇2.239%

26.主题词中同时含有"antiparkinson agents"与"levodopa" 3 篇2.239%

27.主题词中同时含有"genetic vectors"与"recombinant proteins" 3 篇2.239%

28.主题词中同时含有"oxidative stress"与"parkinson disease" 2 篇1.493%

29.主题词中同时含有"apoptosis"与"neuroprotective agents" 2 篇1.493%

30.主题词中同时含有"apoptosis"与"caspase 3" 2 篇1.493%

31.主题词中同时含有"neurons"与"reactive oxygen species" 2 篇1.493%

32.主题词中同时含有"apoptosis"与"mitochondria" 2 篇1.493%

33.主题词中同时含有"antioxidants"与"oxidative stress" 2 篇1.493%

34.主题词中同时含有"gene expression regulation"与"tumor necrosis factor-alpha" 2 篇1.493%

35.主题词中同时含有"apoptosis"与"nerve degeneration" 2 篇1.493%

36.主题词中同时含有"bone marrow cells"与"green fluorescent proteins" 2 篇1.493%

37.主题词中同时含有"lipopolysaccharides"与"nitric oxide" 2 篇1.493%

38.主题词中同时含有"apoptosis"与"gene expression regulation" 2 篇1.493%

39.主题词中同时含有"apoptosis"与"neurons" 1 篇0.746%

40.主题词中同时含有"neurons"与"oxidative stress" 1 篇0.746%

41.主题词中同时含有"nerve degeneration"与"substantia nigra" 1 篇0.746%

42.主题词中同时含有"hippocampus"与"neurons" 1 篇0.746%

43.主题词中同时含有"apoptosis"与"proto-oncogene proteins c-bcl-2" 1 篇0.746%

44.主题词中同时含有"caspase 3"与"proto-oncogene proteins c-bcl-2" 1 篇0.746%

45.主题词中同时含有"antioxidants"与"parkinson disease" 1 篇0.746%

46.主题词中同时含有"hydrogen peroxide"与"neurons" 1 篇0.746%

47.主题词中同时含有"inflammation"与"tumor necrosis factor-alpha" 1 篇0.746%

筛选或者

字段：作者缩写

记录数

占%

01.Kirik D 33 篇1.484%

02.Bankiewicz KS 31 篇1.394%

03.Aebischer P 30 篇1.349%

04.Kordower JH 28 篇1.259%

05.Mandel RJ 26 篇1.169%

06.Baekelandt V 24 篇1.079%

07.Mochizuki H 23 篇1.034%

08.Björklund A 20 篇0.899%

09.Kang UJ 19 篇0.854%

10.Bohn MC 19 篇0.854%

11.Muramatsu S 19 篇0.854%

12.Federoff HJ 18 篇0.809%

13.Ozawa K 18 篇0.809%

14.Forsayeth J 17 篇0.764%

15.During MJ 16 篇0.719%

16.Mallet J 16 篇0.719%

17.Beal MF 15 篇0.674%

18.Jankovic J 15 篇0.674%

19.Mizuno Y 15 篇0.674%

20.Gasser T 15 篇0.674%

21.Wang X 15 篇0.674%

22.Kim KS 14 篇0.629%

23.Bezard E 13 篇0.585%

24.Zhang Y 13 篇0.585%

25.Isacson O 13 篇0.585%

26.Klein C 13 篇0.585%

27.Olanow CW 13 篇0.585%

28.Déglon N 13 篇0.585%

29.Youdim MB 12 篇0.540%

30.Wang Y 12 篇0.540%

31.Chen SD 12 篇0.540%

32.Nagatsu T 12 篇0.540%

33.Riederer P 11 篇0.495%

34.Yang H 11 篇0.495%

35.Mouradian MM 10 篇0.450%

36.Le W 10 篇0.450%

37.Schulz JB 10 篇0.450%

38.Masliah E 9 篇0.405%

39.Mandel S 9 篇0.405%

40.Melamed E 9 篇0.405%

41.Dawson TM 8 篇0.360%

42.Li X 8 篇0.360%

43.Farrer MJ 8 篇0.360%

44.Mattson MP 8 篇0.360%

45.Andersen JK 8 篇0.360%

46.Dawson VL 7 篇0.315%

47.Brice A 7 篇0.315%

48.Zhang J 6 篇0.270%

49.Ariga H 6 篇0.270%

50.Liu Z 5 篇

0.225

筛选或者

字段：国家

记录数

占%

01.美国 767 篇34.487%

02.英国 147 篇6.610%

03.日本 141 篇6.340%

04.中国大陆 134 篇6.025%

05.德国 115 篇5.171%

06.法国 95 篇4.272%

07.意大利 90 篇4.047%

08.瑞典 70 篇3.147%

09.加拿大 67 篇3.013%

10.韩国 55 篇2.473%

11.西班牙 51 篇2.293%

12.瑞士 38 篇1.709%

13.以色列 36 篇1.619%

14.比利时 33 篇1.484%

15.荷兰 18 篇0.809%

16.奥地利 16 篇0.719%

17.墨西哥 16 篇0.719%

18.中国台湾 15 篇0.674%

19.印度 14 篇0.629%

20.新加坡 13 篇0.585%

21.巴西 12 篇0.540%

22.希腊 11 篇0.495%

23.丹麦 11 篇0.495%

24.澳大利亚 10 篇0.450%

25.葡萄牙 10 篇0.450%

26.芬兰 9 篇0.405%

27.波兰 9 篇0.405%

28.匈牙利 8 篇0.360%

29.爱尔兰 8 篇0.360%

30.伊朗 8 篇0.360%

31.阿根廷 6 篇0.270%

32.挪威 5 篇0.225%

33.新西兰 4 篇0.180%

34.古巴 4 篇0.180%

35.斯洛文尼亚 3 篇0.135%

36.沙特阿拉伯 3 篇0.135%

37.智利 2 篇0.090%

38.中国香港 2 篇0.090%

39.克罗地亚 2 篇0.090%

40.南非 2 篇0.090%

41.斯洛伐克 1 篇0.045%

42.巴基斯坦 1 篇

0.045

筛选或者

字段：机构

记录数

占%

01.university of california 56 篇2.518%

02.lund university 42 篇1.888%

03.harvard medical school 36 篇1.619%

04.national institutes of health 27 篇1.214%

05.massachusetts general hospital 23 篇1.034%

06.university college london 23 篇1.034%

07.columbia university 22 篇0.989%

08.wallenberg neuroscience center 21 篇0.944%

09.northwestern university 19 篇0.854%

10.university of florida 18 篇0.809%

11.university of california san francisco 16 篇0.719%

12.jichi medical school 15 篇0.674%

13.baylor college of medicine 14 篇0.629%

14.national institute on aging 14 篇0.629%

15.chinese academy of sciences 14 篇0.629%

16.kyoto university 14 篇0.629%

17.university of pennsylvania 13 篇0.585%

18.katholieke universiteit leuven 13 篇0.585%

19.mayo clinic 12 篇0.540%

20.ruijin hospital 12 篇0.540%

21.capital medical university 12 篇0.540%

22.johns hopkins university school of medicine 11 篇0.495%

23.feinberg school of medicine 11 篇0.495%

24.rush university medical center 11 篇0.495%

25.university of florida college of medicine 11 篇0.495%

26.weill medical college of cornell university 10 篇0.450%

27.university of toronto 10 篇0.450%

28.university of cambridge 10 篇0.450%

29.juntendo university school of medicine 10 篇0.450%

30.university of tubingen 10 篇0.450%

31.toronto western hospital 10 篇0.450%

32.mount sinai school of medicine 9 篇0.405%

33.national institute of neurological disorders and stroke 9 篇0.405%

34.university of pittsburgh 9 篇0.405%

35.university of british columbia 9 篇0.405%

36.karolinska institutet 8 篇0.360%

37.ucl institute of neurology 8 篇0.360%

38.boston university school of medicine 7 篇0.315%

39.emory university school of medicine 7 篇0.315%

40.center for neurosciences 7 篇0.315%

41.massgeneral institute for neurodegenerative disease 7 篇0.315%

42.yale university school of medicine 7 篇0.315%

43.karolinska institute 7 篇0.315%

44.shanghai institutes for biological sciences 7 篇0.315%

45.buck institute for age research 6 篇0.270%

46.hanyang university 6 篇0.270%

47.university of pittsburgh school of medicine 5 篇0.225%

48.stanford university school of medicine 5 篇0.225%

49.kyung hee university 4 篇0.180%

50.university of nebraska medical center 3 篇

0.135

筛选或者

字段：中国省份

记录数

占%

01.上海市 41 篇30.597%

02.北京市 36 篇26.866%

03.湖北省 9 篇6.716%

04.广东省 7 篇5.224%

05.辽宁省 6 篇4.478%

06.云南省 5 篇3.731%

07.江苏省 4 篇2.985%

08.四川省 4 篇2.985%

09.山东省 3 篇2.239%

10.浙江省 3 篇2.239%

11.福建省 2 篇1.493%

12.陕西省 2 篇1.493%

13.天津市 2 篇1.493%

14.重庆市 2 篇1.493%

15.贵州省 1 篇0.746%

16.河南省 1 篇0.746%

17.湖南省 1 篇0.746%

18.海南省 1 篇0.746%

19.黑龙江省 1 篇0.746%

20.河北省 1 篇0.746%

21.安徽省 1 篇

0.746

筛选或者

字段：机构

记录数

占%

01.chinese academy of sciences 14 篇10.448%

02.medical college 14 篇10.448%

03.capital medical university 12 篇8.955%

04.ruijin hospital 12 篇8.955%

05.fudan university 8 篇5.970%

06.capital university of medical sciences 8 篇5.970%

07.peking union medical college 7 篇5.224%

08.shanghai institutes for biological sciences 7 篇5.224%

09.beijing institute for neuroscience 6 篇4.478%

10.shanghai jiaotong university school of medicine 6 篇4.478%

11.peking university 5 篇3.731%

12.union hospital 5 篇3.731%

13.huazhong university of science and technology 4 篇2.985%

14.tongji medical college 4 篇2.985%

15.shanghai jiao tong university school of medicine 4 篇2.985%

16.beijing institute for neurosciences 4 篇2.985%

17.chinese academy of medical science 4 篇2.985%

18.shanghai institute of biochemistry 4 篇2.985%

19.the chinese academy of sciences 3 篇2.239%

20.chinese academy of medical sciences 3 篇2.239%

21.neuroscience research institute 3 篇2.239%

22.shanghai second medical university 3 篇2.239%

23.sichuan university 3 篇2.239%

24.zhujiang hospital 3 篇2.239%

25.the first affiliated hospital 3 篇2.239%

26.chinese academy of medical sciences and peking union medical college 2 篇1.493%

27.neuromedical institute 2 篇1.493%

28.second affiliated hospital 2 篇1.493%

29.zhejiang university 2 篇1.493%

30.rui-jin hospital 2 篇1.493%

31.shenyang pharmaceutical university 2 篇1.493%

32.wuhan university 2 篇1.493%

33.south medical university 2 篇1.493%

34.shanghai institute of materia medica 1 篇0.746%

35.anhui medical university 1 篇0.746%

36.central south university 1 篇0.746%

37.dalian university of technology 1 篇0.746%

38.department of neurology & neuroscience institute 1 篇0.746%

39.second affiliated hospital of soochow university 1 篇0.746%

40.academia sinica 1 篇0.746%

41.1] cell therapy center 1 篇0.746%

42.the fourth military medical university 1 篇0.746%

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