缺氧诱导因子-1 (hypoxia inducible factor-1,HIF-1)是1992年Semenza和Wang首先发现，随后确立了HIF-1的结构，并证明了其cDNA的编码顺序。HIF-1普遍存在于人和哺乳动物细胞内,常氧下(21%O2)也有表达，但合成的HIF-1蛋白很快即被细胞内氧依赖性泛素蛋白酶降解途径所降解，只有在缺氧条件下HIF-1才可稳定表达。HIF-1是具有转录活性的核蛋白，具有相当广泛的靶基因谱，其中包括与缺氧适应、炎症发展及肿瘤生长等相关的近100种靶基因[3,4]。当其与靶基因结合后，通过转录和转录后调控使机体产生一系列反应，有些反应尽管带有适应代偿性质,但也常给机体带来病理性损害，如低氧性肺动脉高压( hypoxic pulmonary hypertension,HPH)、肿瘤加速生长等。http://baike.baidu.com/view/3852943.htm

 "hypoxia-inducible factor 1"[mesh]

基因本体(细胞组件)

01.intracellular    524 篇5.777%

02.chromatin    299 篇3.297%

03.collagen    201 篇2.216%

04.cytoplasm    192 篇2.117%

05.endoplasmic reticulum    168 篇1.852%

06.extracellular matrix    155 篇1.709%

07.cell surface    102 篇1.125%

08.host    99 篇1.092%

09.microtubule    88 篇0.970%

10.plasma membrane    76 篇0.838%

11.chromosome    60 篇0.662%

12.plastoglobule    56 篇0.617%

13.peroxisome    52 篇0.573%

14.ubiquitin ligase complex    51 篇0.562%

15.cytoskeleton    49 篇0.540%

16.nadh dehydrogenase complex    37 篇0.408%

17.mitochondrial respiratory chain    32 篇0.353%

18.transcription factor complex    26 篇0.287%

19.receptor complex    23 篇0.254%

20.basement membrane    21 篇0.232%

21.protein complex    20 篇0.221%

22.m band    18 篇0.198%

23.aryl hydrocarbon receptor complex    16 篇0.176%

24.axon    16 篇0.176%

25.signalosome    7 篇0.077%

26.myelin sheath    6 篇0.066%

27.coated vesicle    5 篇0.055%

28.cytoplasmic mrna processing body    3 篇0.033%

29.cell wall    3 篇0.033%

30.nucleolus organizer region    1 篇0.011%

31.x chromosome    1 篇0.011

基因本体(分子功能)

01.dna binding    1755 篇19.350%

02.rna-directed rna polymerase activity    899 篇9.912%

03.map kinase activity    419 篇4.620%

04.1-phosphatidylinositol-3-kinase activity    238 篇2.624%

05.phenylalanine dehydrogenase activity    231 篇2.547%

06.ethanolamine-phosphate cytidylyltransferase activity    225 篇2.481%

07.ubiquitin-protein ligase activity    224 篇2.470%

08.deoxyribodipyrimidine photo-lyase activity    187 篇2.062%

09.insulin-like growth factor receptor binding    114 篇1.257%

10.acetylene hydratase activity    106 篇1.169%

11.jun kinase activity    94 篇1.036%

12.fibroblast growth factor receptor binding    94 篇1.036%

13.platelet-derived growth factor receptor binding    92 篇1.014%

14.interleukin-6 receptor binding    83 篇0.915%

15.catalytic activity    60 篇0.662%

16.monooxygenase activity    52 篇0.573%

17.kinase activity    49 篇0.540%

18.camp response element binding protein binding    47 篇0.518%

19.superoxide dismutase activity    46 篇0.507%

20.cyclic nucleotide-gated mechanosensitive ion channel activity    40 篇0.441%

21.interleukin-1 receptor binding    33 篇0.364%

22.peroxidase activity    19 篇0.209%

23.protein serine/threonine phosphatase activity    18 篇0.198%

24.tau-protein kinase activity    18 篇0.198%

25.notch binding    5 篇0.055%

26.au-rich element binding    4 篇0.044%

27.cholesterol monooxygenase (side-chain-cleaving) activity    2 篇0.022%

28.nitric oxide binding    1 篇0.011%

29.catechol 1,2-dioxygenase activity    1 篇0.011%

30.gtpase activity    1 篇0.01

基因本体（生物过程）

01.transcription, dna-dependent    5070 篇55.899%

02.biological regulation    4445 篇49.008%

03.growth    3837 篇42.304%

04.biosynthetic process    2784 篇30.695%

05.angiogenesis    1914 篇21.103%

06.signaling    1897 篇20.915%

07.signal transduction    1744 篇19.228%

08.developmental process    1533 篇16.902%

09.apoptosis    1200 篇13.230%

10.regulation of cell cycle    998 篇11.003%

11.homeostatic process    472 篇5.204%

12.cell cycle    438 篇4.829%

13.rna interference    435 篇4.796%

14.glycolysis    412 篇4.542%

15.translation    348 篇3.837%

16.cell growth    294 篇3.241%

17.localization    246 篇2.712%

18.erythrocyte differentiation    173 篇1.907%

19.behavior    169 篇1.863%

20.aging    165 篇1.819%

21.vascular endothelial growth factor production    125 篇1.378%

22.tube formation    114 篇1.257%

23.epithelial to mesenchymal transition    95 篇1.047%

24.proteolysis    85 篇0.937%

25.autophagy    84 篇0.926%

26.oxidative phosphorylation    82 篇0.904%

27.cell cycle arrest    80 篇0.882%

28.ossification    72 篇0.794%

29.embryo development    66 篇0.728%

30.tricarboxylic acid cycle    61 篇0.673%

31.cellular metabolic process    61 篇0.673%

32.protein catabolic process    61 篇0.673%

33.female pregnancy    60 篇0.662%

34.vasculogenesis    52 篇0.573%

35.protein stabilization    49 篇0.540%

36.anatomical structure morphogenesis    42 篇0.463%

37.s phase    39 篇0.430%

38.post-translational protein modification    35 篇0.386%

39.m phase    14 篇0.154%

40.notch signaling pathway    9 篇0.099%

41.t cell differentiation    8 篇0.088%

42.b cell differentiation    4 篇0.044%

43.t cell proliferation    3 篇0.033%

44.nitric oxide homeostasis    2 篇0.022%

45.b cell proliferation    2 篇0.022%

研究主题领域

01.hypoxia-inducible factor 1    9070 篇100.000%

02.transcription factors    9070 篇100.000%

03.basic helix-loop-helix transcription factors    9070 篇100.000%

04.dna-binding proteins    9070 篇100.000%

05.hypoxia-inducible factor 1, alpha subunit    7228 篇79.691%

06.cells, cultured    4378 篇48.269%

07.gene expression regulation    3909 篇43.098%

08.neoplasms    3397 篇37.453%

09.cell line    3028 篇33.385%

10.tumor cells, cultured    2605 篇28.721%

11.cell hypoxia    2434 篇26.836%

12.cell line, tumor    2136 篇23.550%

13.vascular endothelial growth factor a    2075 篇22.878%

14.nuclear proteins    2005 篇22.106%

15.anoxia    1709 篇18.842%

16.rna, messenger    1692 篇18.655%

17.signal transduction    1624 篇17.905%

18.gene expression    1306 篇14.399%

19.immunohistochemistry    1277 篇14.079%

20.base sequence    1133 篇12.492%

21.oxygen    1112 篇12.260%

22.neovascularization, pathologic    940 篇10.364%

23.gene expression regulation, neoplastic    908 篇10.011%

24.models, biological    852 篇9.394%

25.cell proliferation    850 篇9.372%

26.blotting, western    848 篇9.350%

27.apoptosis    841 篇9.272%

28.reverse transcriptase polymerase chain reaction    836 篇9.217%

29.promoter regions, genetic    777 篇8.567%

30.up-regulation    775 篇8.545%

31.aryl hydrocarbon receptor nuclear translocator    771 篇8.501%

32.transcription, genetic    742 篇8.181%

33.molecular sequence data    732 篇8.071%

34.antineoplastic agents    722 篇7.960%

35.transfection    655 篇7.222%

36.disease models, animal    639 篇7.045%

37.rna, small interfering    566 篇6.240%

38.receptors, aryl hydrocarbon    536 篇5.910%

39.time factors    521 篇5.744%

40.reactive oxygen species    516 篇5.689%

41.transcriptional activation    515 篇5.678%

42.mice, inbred c57bl    510 篇5.623%

43.von hippel-lindau tumor suppressor protein    502 篇5.535%

44.rats, sprague-dawley    480 篇5.292%

45.procollagen-proline dioxygenase    478 篇5.270%

46.cell survival    476 篇5.248%

47.protein binding    456 篇5.028%

48.neovascularization, physiologic    439 篇4.840%

49.phosphorylation    420 篇4.631%

50.down-regulation    396 篇4.366%