博文
睾丸大小与心脏病关联的知识发现
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知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
较大睾丸可能暗示心脏病
研究测量了 2800 名寻求性功能障碍治疗的意大利男子的睾丸大小，并持续关注他们的状况长达 7 年。研究人员意外的发现心脏疾病的风险因素——例如肥胖症、吸烟和高血压——与较大的睾丸存在直接的联系。 较大睾丸的男子因心脏疾病入院就医的风险也相对更大。研究人员还发现高含量的黄体化激素（luteinizing hormone, LH）——由脑下垂体分泌，能够刺激睾丸素的产生——与增加的心脏疾病风险有关。即使研究人员考虑了心脏疾病的风险因素，这种关联依然存在。 http://www.bio360.net/news/show/6500.html
原文如下：
Relationship of TestisSize and LHLevels with Incidence of MajorAdverseCardiovascularEvents in OlderMen with SexualDysfunction. 性功能障碍老年人的睾丸大小和LHL水平与主要心血管事件的关系
Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Measurement of testis volume (TV) is a reliable clinical procedure that predicts reproductive fitness. However, the role of TV in overall and cardiovascular (CV) fitness has never been studied.
AIM:The study aims to analyze the clinical correlates of TV in patients with sexualdysfunction (SD) and to verify the value of this parameter and its determinants (i.e., luteinizing hormone [LH] levels) in predicting majoradverse CV events (MACE).
METHODS:A consecutive series of 2,809 subjects without testiculopathy (age 51.2 ± 13.1) consulting for SD was retrospectively studied. A subset of this sample (n = 1,395) was enrolled in a longitudinal study.
MAIN OUTCOME MEASURES:Several clinical and biochemical parameters were investigated.
RESULTS:After adjusting for confounders, TV was negatively associated with both LH (Adj. r = -0.234; P < 0.0001) and follicle-stimulating hormone (Adj. r = -0.326; P < 0.0001). In addition, overweight/obesity, smoking, and alcohol abuse increased as a function of TV (hazard ratio [HR] = 1.041 [1.021-1.061], P < 0.0001; 1.024 [1.005-1.044], P = 0.012; 1.063 [1.015-1.112], P = 0.009, respectively). Furthermore, mean blood pressure was positively related to increased TV (Adj. r = 0.157; P < 0.0001). The effect of these lifestyle factors on TV were only partially related to changes in gonadotropin levels. In the longitudinal analysis, after adjusting for confounders, TV was associated with a higher incidence of MACE (HR = 1.066 [1.013-1.122]; P = 0.014), and the stepwise introduction in the Cox model of lifestyle factors, mean blood pressure and body mass index progressively smoothed out the association, which was no longer statistically significant in the fully adjusted model. Conversely, the association of higher LHlevels with increased incidence of MACE was not attenuated by the progressive introduction of the aforementioned confounders in the model.
CONCLUSIONS:Our data show that in SD subjects, TV and LH are associated with an adverse CV risk profile that mediate the higher TV-associated incidence of MACE. High LHlevels are an independent marker of CV risk. Further studies are needed for clarifying determinants and mechanisms of testis enlargement that, beyond gonadotropins, could mediate the increased incidence of MACE. Rastrelli G, Corona G, Lotti F, Boddi V, Mannucci E, and Maggi M. Relationship of testissize and LHlevels with incidence of majoradversecardiovascularevents in oldermen with sexualdysfunction. J Sex Med **;**:**-**.
© 2013 International Society for Sexual Medicine.
CardiovascularEvents, Hypertension, Luteinizing Hormone, Testis Volume, Testosterone
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
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| A-query: Cardiovascular Events C-query: Testis Size The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 4 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 15874 and can be accessed from the start page after you leave this session. There are 943 terms on the current B-list (发现265个睾丸大小与心脏病关联的基因、蛋白质研究相关知识概念，这些知识概念是文献中隐含的知识点，称为非相关文献的知识概念，也称隐性知识，这些文献之间没有引证关系（引用或互引），科研人员可以去分析这些知识点，也许从中获得科研启发，对科研选题有所帮助；也许对正在进行中的科研工作有参考意义。265are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.
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| Articles that are in both the A and C literature1: Relationship of Testis Size and LH Levels with Incidence of Major Adverse Cardiovascular Events in Older Men with Sexual Dysfunction. 2013 Add to clipboard 2: Effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats. 2006 3: Chronic administration of nandrolone decanoate does not increase the plasma homocysteine level of male rats. 2005 4: TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog. 1999
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Genes & Molecular Sequences, and Gene & Protein Names
943 B-terms left after filter executed Mon Aug 5 19:22:50 2013
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64 rho kinase
65 gene family
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265 axis
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