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进行性骨化性肌炎,100多年全球没有有效的治疗方法

已有 4804 次阅读 2013-7-30 20:46 |个人分类:遗传病学|系统分类:科研笔记| 进行性

 

进行性骨化性肌炎(MOP)又叫进行性骨化性纤维发育不良(FOP),是一种罕见的遗传性、进行性结缔组织疾患,以先天性拇指畸形和进行性横纹肌骨化为特征。国外统计其发病率约为1/200万,无性别、种族等差异,而据国内报道男性略多于女性。http://baike.baidu.com/view/3439289.htm

17岁少女患怪病恐变“活雕像” http://www.chinanews.com/gj/2013/07-30/5099339.shtml

17岁少女患怪病恐变“活雕像”仍积极生活(图)

 

从1907年至今,全球大概有700例,至今还没有有效的治疗方法,激素治疗、物理疗法、放射疗法、外科手术都不管用。

Fibrodysplasia Ossificans Progressiva

1 2 3 ...189 
Top Terms
Publications
 
Myositis Ossificans
 
1,973
Humans
 
1,544
Myositis
 
1,229
Adult
 
655
Patients
 
505
Child
 
474
Tissues
 
451
Adolescent
 
439
Muscles
 
433
Diagnosis
 
429
Diagnosis, Differential
 
417
Ossification, Heterotopic
 
348
Middle Aged
 
338
Child, Preschool
 
234
Wounds and Injuries
 
233
Neoplasms
 
211
Osteogenesis
 
198
ossification
 
196
Tomography, X-Ray Computed
 
181
Aged
 
161
1 2 3 ...189 
1 2 3 4 5 
Top Years
Publications
 
2012
 
77
2011
 
65
2010
 
65
1998
 
58
2009
 
50
2008
 
46
2006
 
46
1995
 
41
2007
 
40
1999
 
39
1992
 
39
2005
 
38
1976
 
38
1967
 
38
1994
 
37
2000
 
36
2003
 
36
1996
 
36
1990
 
35
2004
 
34
1 2 3 4 5 
1 2 3 4 
Top Countries
Publications
 
United States
 
335
United Kingdom
 
67
Japan
 
58
France
 
45
India
 
42
Italy
 
38
Germany
 
36
Turkey
 
34
China
 
27
Belgium
 
25
Spain
 
22
Australia
 
16
Brazil
 
14
South Korea
 
13
Canada
 
13
Netherlands
 
13
Switzerland
 
11
Israel
 
10
Iran
 
7
Taiwan
 
7
1 2 3 4 
1 2 3 ...20 
Top Cities
Publications
 
Philadelphia
 
95
Paris
 
16
London
 
15
Boston
 
14
New York City
 
14
Tokyo
 
10
İstanbul
 
10
Oxford
 
9
New Delhi
 
9
Ankara
 
8
Madrid
 
7
Roma
 
7
Leuven
 
7
Beijing
 
7
Washington, D.C.
 
7
Baltimore
 
7
Brussels
 
7
İzmir
 
6
Saitama
 
6
Saint Louis
 
6
1 2 3 ...20 
1 2 3 ...40 
Top Journals
Publications
 
Clin Orthop Relat R
 
69
J Bone Joint Surg Am
 
48
Skeletal Radiol
 
38
Proc R Soc Med
 
36
Clin Nucl Med
 
23
J Bone Joint Surg Br
 
20
Orthopedics
 
15
Pediatr Radiol
 
14
J Bone Miner Res
 
13
Acta Orthop Belg
 
13
J Radiol
 
13
Am J Roentgenol
 
13
Am J Med Genet A
 
12
Radiology
 
12
Rofo-fortschr Rontg
 
12
Z Orthop Grenzgeb
 
12
Acta Chir Orthop Traumatol Cech
 
11
Indian Pediatr
 
11
Oral Surg Oral Med Oral Pathol
 
11
Clin Radiol
 
10
1 2 3 ...40 
1 2 3 ...282 
Top Authors
Publications
 
Kaplan F
 
76
Shore E
 
49
Zasloff M
 
32
Gannon F
 
15
Glaser D
 
13
Rocke D
 
10
Hahn G
 
9
Connor J
 
9
Billings P
 
7
Tabas J
 
7
Kransdorf M
 
6
Michelsson J
 
6
Evans D
 
6
Witwicki T
 
6
Le Merrer M
 
5
Lucotte G
 
5
Fiori J
 
5
McCarthy E
 
5
Feldman G
 
5
Connor J
 
5
1 2 3 ...282 
publications over timepublications over timeworld map network of top authorsnetwork of top authorsnetwork of top authors-Legend

http://www.gopubmed.org/web/gopubmed/16?WEB01n93bmnimykz5I2I1I00h001000d10021000300.y



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