刘桂锋：许教授，最近对知识发现感兴趣，有时间多指点，谢谢。

刘老师，您好。http://arrowsmith.psych.uic.edu/arrowsmith_uic/index.html 主要用于生物医学领域的知识发现，我不太了解国内外其他学科领域有没有知识发现的系统？我觉得情报界对信息检索与分析已经非常熟悉并重视，但对知识发现不太熟悉和应用。因此我多做些实例介绍，希望科研人员，特别是情报人员能多研究和应用。

      果蝇脑肿瘤基因brat（brain tumor）是一个进化上非常保守的基因，该基因突变后导致果蝇大脑产生肿瘤，造成大脑半球明显增大。brat突变体的神经肌肉突触过度生长，其显著特征是突触卫星扣结数大大增加。同时，电镜实验结果表明，与野生型相比，brat突变体突触扣结负责神经递质传递的活性区的大小增大。http://www.ebiotrade.com/newsf/2013-7/2013729113415758.htm

脑肿瘤蛋白Brat的知识发现

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

A-query: brat
C-query: brain tumor

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 134 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 755 and can be accessed from the start page after you leave this session. There are 149 terms on the current B-list (发现27个遗传基因相关的知识概念，对科研人员有启发作用和参考意义 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 755 started Sun Jul 28 23:51:07 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: bratSun Jul 28 23:51:27 2013

A query = brat started Sun Jul 28 23:51:27 2013
A query resulted in 398 titles
C_query_raw: brat Sun Jul 28 23:51:31 2013

C: brat 398

A: pubmed_query_A 398

AC: ( brat ) AND ( brat ) 398

C_query_raw: brain tumor Sun Jul 28 23:51:40 2013

C: brain tumor 155751

A: pubmed_query_A 398

AC: ( brat ) AND ( brain tumor ) 134

C_query_raw: brain tumor Sun Jul 28 23:51:44 2013

C: brain tumor 155751

A: pubmed_query_A 398

AC: ( brat ) AND ( brain tumor ) 134

C query = brain tumor started Sun Jul 28 23:51:44 2013
C query resulted in 50000 titles
A AND C query resulted in 134 titles
1739 B-terms ready on Sun Jul 28 23:52:04 2013

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
149 B-terms left after filter executed Sun Jul 28 23:52:54 2013

B-list on Sun Jul 28 23:58:24 2013
1 akt
2 vegf
3 caspase
4 pten
5 microrna
6 brca1
7 meningioma
8 maspin
9 transcription factor
10 cancer gene therapy
11 let-7
12 jak2
13 1p
14 map kinase
15 tumor suppressor
16 p42
17 tgf beta
18 early growth response
19 ubiquitin
20 bmp
21 olig2
22 vegf a
23 tuberous sclerosis
24 hiv
25 idh1
26 fgf
27 targeted cancer gene

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=755

brat基因与 akt基因或脑肿瘤的关系研究文献如下：

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

2009国家自然科学基金项目（生物类）http://cache.baiducontent.com/c?m=9d78d513d9d430a94f9b92690c66c0101d43f6662ba6d3020bd08449e3732b315012e8ac51220770d3d27d1751ef1a1afeb7762c385966f1d9df8939c0a6c57768d97d23706bda1654ce43e9941838c1229251eba404e4bdf13097aad0c4df23098c0c5b&p=8b2a975b8c8c11a058ee9f2c5c00cf&newp=86759a45d5c813fa05be9b7c150581231610db2151d1d4142d81ce&user=baidu&fm=sc&query=%C4%D4%D6%D7%C1%F6%BB%F9%D2%F2brat&qid=&p1=8
中国科学院遗传与发育生物学研究所  180  脑肿瘤基因brat与脆性X智力低下基因dfmr1 的互作及其在神经突触的功能  张永清  30930033/C090203  2010-01至2013-12