terahertz 刘桂锋

许教授，最近对知识发现感兴趣，有时间多指点，谢谢。

刘老师，您好。http://arrowsmith.psych.uic.edu/arrowsmith_uic/index.html 主要用于生物医学领域的知识发现，我不太了解国内外其他学科领域有没有知识发现的系统？我觉得情报界对信息检索与分析已经非常熟悉并重视，但对知识发现不太熟悉和应用。因此我多做些实例介绍，希望科研人员，特别是情报人员能多研究和应用。

      相信每个人周遭都会遇到一些常常郁郁寡欢的朋友，也会有一些终日笑脸迎人的开心果，但这些人的差异是天生的吗？还是後天的长成或是环境造成的呢？在多数的情形下，每个人的状态都是由诸多复杂因素所塑造的，这次要介绍的研究想要特别针对基因及後天的长成来作探讨。

       这次研究针对的基因型是一个与血清素(serotonin)传递有关系的5-HTTLPR基因，这个基因型过去已经被发现和情绪的处理非常有关系，特别是负向情绪的处理。这个基因如同其他基因一样，有所谓的长或短的版本，如果个体带有短的版本，则会强化对於负向刺激的处理、减弱对於正向刺激的处理。

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=1095

知识发现结果如下

Start A-Literature C-Literature B-list Filter Literature

​

A-query: serotonin C-query: 5-HTTLPR The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1230 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 1095 and can be accessed from the start page after you leave this session. There are 442 terms on the current B-list (发现99个非相关文献知识概念，这些知识点也许有重要意义，对科研人员有启发和参考价值 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 1095 started Thu Jul 25 19:36:09 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: serotoninThu Jul 25 19:36:23 2013

A query = serotonin started Thu Jul 25 19:36:23 2013
A query resulted in 50000 titles
C_query_raw: serotonin Thu Jul 25 19:36:30 2013

C: serotonin 121800

A: pubmed_query_A 121800

AC: ( serotonin ) AND ( serotonin ) 121800

C_query_raw: 5-HTTLPR Thu Jul 25 19:36:43 2013

C: 5-HTTLPR 1273

A: pubmed_query_A 121800

AC: ( serotonin ) AND ( 5-HTTLPR ) 1230

C_query_raw: 5-HTTLPR Thu Jul 25 19:36:51 2013

C: 5-HTTLPR 1273

A: pubmed_query_A 121800

AC: ( serotonin ) AND ( 5-HTTLPR ) 1230

C query = 5-HTTLPR started Thu Jul 25 19:36:51 2013
C query resulted in 1273 titles
A AND C query resulted in 1230 titles
442 B-terms ready on Thu Jul 25 19:36:59 2013

B-list on Thu Jul 25 19:40:55 2013
1 panic disorder
2 escitalopram
3 risperidone
4 sertraline
5 bdnf
6 paroxetine
7 5-htt
8 fluvoxamine
9 panic
10 major depressive disorder
11 major depressive
12 anxiety depression
13 sert
14 pharmacogenomic
15 environment interaction
16 major depression
17 gene polymorphism
18 candidate gene
19 htr1a
20 gene environment
21 poststroke depression
22 serotonergic gene
23 major depression a
24 bipolar disorder
25 depressive symptom
26 anxiety disorder
27 polymorphism associated
28 drd4
29 val66met
30 traumatic stress disorder
31 response sertraline
32 response emotional face
33 pharmacogenetic
34 meta analysis
35 post traumatic stress
36 serotonergic
37 transcranial direct current
38 life event
39 genetic polymorphism
40 poststroke
41 transcranial direct
42 bdnf val66met
43 depressive
44 amygdala
45 association study
46 comt
47 amygdala response emotional
48 depressive disorder
49 amygdala response
50 drd2
51 response risperidone
52 sertraline versus
53 aldh2
54 gene x environment
55 val158met
56 functional gene variant
57 stressful life event
58 serotonergic system
59 alzheimer disease
60 anxiety
61 antidepressant efficacy
62 maternal depressive
63 response sertraline versus
64 healthy volunteer
65 paroxetine fluvoxamine
66 alzheimer
67 allostatic load
68 genetic alzheimer disease
69 emotional face
70 polymorphism
71 gene environment interaction
72 gene 5-htt
73 comt val158met
74 transcranial
75 plasticity
76 hippocampal volume
77 gene variant
78 polymorphism moderate
79 x environment
80 x environment interaction
81 gsk3beta
82 aldh2 gene
83 cck-4
84 traumatic stress
85 opiate
86 comprehensive meta
87 depression a comprehensive
88 treatment escitalopram
89 stress disorder
90 genotyping
91 emotion processing
92 alcohol opiate
93 imaging
94 depressed patient
95 depression
96 bdnf polymorphism
97 life stress
98 cck-4 challenge
99 personality trait

 

恐慌症与5-HTTLPR基因的关系研究

Start A-Literature C-Literature B-list Filter Literature

​

AB literature   B-term   BC literature   serotonin panic disorder 5-HTTLPR 1: Clonazepam for the treatment of panic disorder. 2013 Add to clipboard 2:Panic disorder and migraine: comorbidity, mechanisms, and clinical implications. 2013 Add to clipboard 3: Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. 2013 Add to clipboard 4: Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. 2013 Add to clipboard 5: Cost-effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder. 2013 Add to clipboard 6: Treatment strategies of obsessive-compulsive disorder and panic disorder/agoraphobia. 2012 Add to clipboard 7: Citalopram-induced major depression in a patient with panic disorder - a case report. 2012 Add to clipboard 8:Panic disorder and school refusal. 2012 Add to clipboard 9: Regional Brain Metabolism and Treatment Response in Panic Disorder Patients: An [F]FDG-PET Study. 2012 Add to clipboard 10: Gender-specific abnormalities in the serotonin transporter system in panic disorder. 2012 Add to clipboard 11: Changes in gray matter volume of remitted first-episode, drug-naive, panic disorder patients after 6-week antidepressant therapy. 2012 Add to clipboard 12: Newer antidepressants and panic disorder: a meta-analysis. 2012 Add to clipboard 13: Novel antidepressants and panic disorder: evidence beyond current guidelines. 2011 Add to clipboard 14: New treatment options for panic disorder: clinical trials from 2000 to 2010. 2011 Add to clipboard 15: Predictors of outcome of pharmacological and psychological treatment of late-life panic disorder with agoraphobia. 2011 Add to clipboard 16:Panic disorder and suicidal behavior. 2011 Add to clipboard 17: Evidence-based pharmacotherapy of panic disorder: an update. 2011 Add to clipboard 18: Milnacipran in panic disorder with agoraphobia and major depressive disorder: a case report. 2011 Add to clipboard 19:Serotonin-2a receptor and catechol-O-methyltransferase polymorphisms in panic disorder. 2011 Add to clipboard 20: Efficacy of a specific model for cognitive-behavioral therapy among panic disorder patients with agoraphobia: a randomized clinical trial. 2011 Add to clipboard 21: A Randomized, Naturalistic, Parallel-Group Study for the Long-Term Treatment of Panic Disorder With Clonazepam or Paroxetine. 2011 Add to clipboard

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

转载本文请联系原作者获取授权，同时请注明本文来自许培扬科学网博客。
链接地址：https://blog.sciencenet.cn/blog-280034-711323.html

上一篇：许博主的图书馆读者，富人多、年轻人多
下一篇：国内外科研动态 7月26日