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诺奖得主澳大利亚Marshall BJ教授的科学贡献

已有 1823 次阅读 2016-10-26 19:29 |个人分类:诺贝尔奖|系统分类:人物纪事


       Barry J. Marshall(1951年9月30日~)澳大利亚科学家,与罗宾·沃伦(J. Robin Warren)发现了幽门螺杆菌(Helicobacter pylori,Hp)以及这种细菌在胃炎和胃溃疡等疾病中的作用,被授与2005年诺贝尔生理或医学奖。2011年,被评为中国工程院外籍院士。http://baike.so.com/doc/5612512-5825122.html

       20世纪中叶,大多数医生认为胃溃疡是由于焦虑,辛辣食物或酸性物质过多引起的,而只能通过卧床休息,防酸片治疗,实在不行就要手术治疗。

       然而在1979年,澳大利亚病理学家Robin Warren做胃组织炎症活检时发现出现有微小弯曲的细菌菌落存在。

       另一位澳洲医生Barry Marshall得讯后和他联系组队,两人进行了100例胃溃疡活检。

       他们的研究结果表明,细菌是导致胃溃疡和胃炎的原因,他们把这种细菌命名为幽门螺旋杆菌,但持怀疑态度的医学界认为他们的证据还不够充分。

       因为没有动物适合作为人类这种疾病研究的替代模型,Barry 勇敢地喝下了含有细菌的培养液。五天后,他失去了胃口,然后每天早晨呕吐。内窥镜检查发现,他确实染上胃炎。Barry 然后开始一个疗程的抗生素,症状消失 (幽门螺旋杆菌引发胃溃疡,长期发展会导致胃癌几率大大提高。所以要及时治疗)。

http://blog.sciencenet.cn/blog-274385-1010458.html

PUBMED数据库检索到论文38篇  

pubmed_result  38篇.txt

https://academic.microsoft.com/#/search?iq=Composite(AA.AuN%3D%3D'barry%20marshall')&q=barry%20marshall&filters=&from=0&sort=0

数据来源 http://www.pubmedplus.cn/


年份年份趋势图
记录数
占%
01.2016     6 10.714%
02.2015     5 8.929%
03.2014     7 12.500%
04.2013     7 12.500%
05.2010     2 3.571%
06.2009     2 3.571%
07.2008     5 8.929%
08.2007     4 7.143%
09.2006     3 5.357%
10.2005     6 10.714%
11.2010     2 3.571%
12.2009     2 3.571%
13.2004     2 3.571%
14.2003     2 3.571%
期刊期刊分区中科院期刊分区
记录数
占%
01.plos one     5 8.929%
02.helicobacter     4 7.143%
03.appl environ microbiol     2 3.571%
04.gut pathog     2 3.571%
05.infect immun     2 3.571%
06.int j epidemiol     2 3.571%
07.j gastroenterol hepatol     2 3.571%
08.keio j med     2 3.571%
09.med j aust     2 3.571%
10.am j clin nutr     1 1.786%
11.ann intern med     1 1.786%
12.antimicrob agents chemother     1 1.786%
13.anz j surg     1 1.786%
14.aust fam physician     1 1.786%
15.bmc genomics     1 1.786%
16.can j gastroenterol     1 1.786%
17.cancer res     1 1.786%
18.chemmedchem     1 1.786%
19.clin chem     1 1.786%
20.clin med     1 1.786%
21.digestion     1 1.786%
22.febs lett     1 1.786%
23.future microbiol     1 1.786%
24.hum reprod     1 1.786%
25.int j hematol     1 1.786%
26.j bacteriol     1 1.786%
27.j drug target     1 1.786%
28.j gastroenterol     1 1.786%
29.j law med     1 1.786%
30.j microbiol methods     1 1.786%
32.j nutr     1 1.786%
33.jama     1 1.786%
34.med clin north am     1 1.786%
35.nat commun     1 1.786%
36.nature     1 1.786%
37.nucleic acids res     1 1.786%
38.pathology     1 1.786%
39.prog transplant     1 1.786%
40.science     1 1.786%
41.vet res     1 1.786%
国家国家分布图
记录数
占%
01.澳大利亚     30 53.571%
02.美国     7 12.500%
03.英国     4 7.143%
04.新加坡     3 5.357%
05.马来西亚     3 5.357%
06.中国大陆     2 3.571%
07.日本     2 3.571%
08.印度     1 1.786%
09.德国     1 1.786%
10.瑞典     1 1.786%
11.瑞士     1 1.786%
12.荷兰     1 1.786%
11.瑞士     1 1.786%
12.荷兰     1 1.786%
大陆城市境外城市
记录数
占%
01.nedlands     14 25.000%
02.澳大利亚珀斯     13 23.214%
03.kuala     3 5.357%
04.新加坡市     3 5.357%
05.马来西亚吉隆坡     3 5.357%
06.coleraine     2 3.571%
07.menlo park     2 3.571%
08.pacific grove     2 3.571%
09.戴维斯(加州大学戴维斯分校)     2 3.571%
10.日本东京     2 3.571%
查看更多
大陆作者作者与主题词全部作者作者邮件
没有聚类出数据
大陆机构第一作者机构合著机构境外机构
记录数
占%
01.西澳大学     27 48.214%
02.school of pathology     10 17.857%
03.sir charles gairdner hospital     4 7.143%
04.马来亚大学     3 5.357%
05.加州大学     2 3.571%
06.南洋理工大学     2 3.571%
07.墨尔本大学     2 3.571%
08.宾夕法尼亚州立大学     2 3.571%
09.庆应义塾大学     2 3.571%
10.日本庆应义塾大学医学部     2 3.571%
11.阿尔斯特大学     2 3.571%
12.marshall centre for infectious disease research & training     1 1.786%
13.marshall centre for infectious disease research and training     1 1.786%
14.national cancer centre     1 1.786%
15.new england biolabs     1 1.786%
16.the university of western aus     1 1.786%
17.the university of western austra     1 1.786%
18.university of zurich     1 1.786%
19.加州大学戴维斯分校     1 1.786%
20.卫理公会大学     1 1.786%
21.卫理公会大学医院     1 1.786%
22.印度理工学院     1 1.786%
23.哥德堡大学sahlgrenska学院     1 1.786%
24.根特大学     1 1.786%
25.海得拉巴大学     1 1.786%
26.犹他大学     1 1.786%
27.瑞典卡罗琳斯卡医学院     1 1.786%
28.苏格兰ninewells医院和医学院     1 1.786%
29.苏格兰邓迪大学     1 1.786%
30.苏黎世大学     1 1.786%
31.莫道克大学     1 1.786%
32.赫尔辛基大学     1 1.786%
33.都柏林大学     1 1.786%
34.阿姆斯特丹自由大学     1 1.786%
主题词主题词搭配主题词与主题词
记录数
占%
01.helicobacter pylori     32 57.143%
02.helicobacter infections     24 42.857%
03.gastric mucosa     6 10.714%
04.history, 20th century     6 10.714%
05.peptic ulcer     6 10.714%
06.bacterial proteins     4 7.143%
07.breath tests     4 7.143%
08.drug therapy, combination     4 7.143%
09.gastritis     4 7.143%
10.molecular sequence data     4 7.143%
11.phylogeny     4 7.143%
12.stomach neoplasms     4 7.143%
13.anti-bacterial agents     3 5.357%
14.bacterial adhesion     3 5.357%
15.genome, bacterial     3 5.357%
16.history, 21st century     3 5.357%
17.mutation     3 5.357%
18.nobel prize     3 5.357%
19.stomach     3 5.357%
20.stomach ulcer     3 5.357%
21.urea     3 5.357%
22.urease     3 5.357%
23.virulence     3 5.357%
24.cell line     2 3.571%
25.dietary supplements     2 3.571%
26.dna, bacterial     2 3.571%
27.duodenal ulcer     2 3.571%
28.enzyme-linked immunosorbent assay     2 3.571%
29.epithelial cells     2 3.571%
30.evolution, molecular     2 3.571%
31.folic acid     2 3.571%
32.food, fortified     2 3.571%
33.genes, reporter     2 3.571%
34.genetic vectors     2 3.571%
35.gerbillinae     2 3.571%
36.macaca mulatta     2 3.571%
37.mice, inbred c57bl     2 3.571%
38.pregnancy     2 3.571%
39.protein structure, tertiary     2 3.571%
40.proton pumps     2 3.571%
41.rna, messenger     2 3.571%
42.sequence analysis, dna     2 3.571%
43.stomach diseases     2 3.571%
44.thiazoles     2 3.571%
45.treatment outcome     2 3.571%
46.adaptation, biological     1 1.786%
47.adaptation, physiological     1 1.786%
48.adenocarcinoma     1 1.786%
49.adhesins, bacterial     1 1.786%
50.advisory committees     1 1.786%
Substance化学药中药
记录数
占%
01.bacterial proteins     4 7.143%
02.anti-bacterial agents     3 5.357%
03.urea     3 5.357%
04.urease     3 5.357%
05.dna, bacterial     2 3.571%
06.folic acid     2 3.571%
07.proton pumps     2 3.571%
08.rna, messenger     2 3.571%
09.thiazoles     2 3.571%
10.1,2-dielaidoylphosphatidylethanolamine     1 1.786%
查看更多
疾病症状治疗方法物种解剖食品
记录数
占%
01.细菌感染     25 44.643%
02.螺杆菌感染     24 42.857%
03.细菌感染与真菌病     23 41.071%
04.革兰氏阴性菌感染     23 41.071%
05.感染     19 33.929%
06.消化系统疾病     16 28.571%
07.胃肠疾病     15 26.786%
08.扭伤与劳损     14 25.000%
09.胃疾病     13 23.214%
10.消化性溃疡     10 17.857%
11.肠道疾病     8 14.286%
12.肿瘤     8 14.286%
13.胃炎     8 14.286%
14.十二指肠疾病     7 12.500%
15.胃癌     7 12.500%
16.消化系统肿瘤     5 8.929%
17.胃肠癌     5 8.929%
18.十二指肠溃疡     3 5.357%
19.淋巴瘤     3 5.357%
20.胃溃疡     3 5.357%
21.胃肠炎     3 5.357%
22.血液和淋巴系统疾病     3 5.357%
23.先天性畸形     2 3.571%
24.先天性遗传性新生儿疾病和畸形     2 3.571%
25.免疫增生性疾病     2 3.571%
26.免疫系统疾病     2 3.571%
27.淋巴系统疾病     2 3.571%
28.淋巴组织增生性疾病     2 3.571%
29.神经管缺损     2 3.571%
30.神经系统畸形     2 3.571%
31.神经系统疾病     2 3.571%
32.萎缩性胃炎     2 3.571%
33.边缘区b细胞淋巴瘤     2 3.571%
34.b细胞淋巴瘤     1 1.786%
35.乳腺疾病     1 1.786%
36.乳腺癌     1 1.786%
37.传染病     1 1.786%
38.前列腺疾病     1 1.786%
39.前列腺癌     1 1.786%
40.动物传染病     1 1.786%
41.动物疾病     1 1.786%
42.单纯疱疹     1 1.786%
43.吞咽障碍     1 1.786%
44.多发性硬化     1 1.786%
45.寄生虫病     1 1.786%
46.心肌缺血     1 1.786%
47.心脏病     1 1.786%
48.泌尿生殖系统癌     1 1.786%
49.激素依赖性癌     1 1.786%
50.男(雄)性生殖器疾病     1 1.786%
科室学科
记录数
占%
01.school of pathology & laboratory medicine     6 10.714%
02.school of pathology and laboratory medicine     5 8.929%
03.department of gastroenterology     4 7.143%
04.department of medicine     4 7.143%
05.department of medical microbiology     3 5.357%
06.department of microbiology     3 5.357%
07.center for comparative medicine     2 3.571%
08.department of internal medicine     2 3.571%
09.department of pathology     2 3.571%
10.school of biomedical sciences     2 3.571%
11.school of chemistry and biochemistry     2 3.571%
12.1] center for comparative genomics and bioinformatics     1 1.786%
13.center for comparative genomics and bioinformatics     1 1.786%
14.center for microscopy and image analysis     1 1.786%
15.department of basic medical sciences     1 1.786%
16.department of biochemistry and microbiology     1 1.786%
17.department of biochemistry and molecular biology     1 1.786%
18.department of biomedical science     1 1.786%
19.department of biotechnology and bioinformatics     1 1.786%
20.department of food hygiene and environmental health     1 1.786%
21.department of medical biochemistry and cell biology     1 1.786%
22.department of medicine and microbiology     1 1.786%
23.department of molecular biology     1 1.786%
24.department of morphology     1 1.786%
25.department of neurology     1 1.786%
26.department of social and preventive medicine     1 1.786%
27.division of gastroenterology and hepatology     1 1.786%
28.institute of biomedicine     1 1.786%
29.institute of child health     1 1.786%
30.jean mayer usda human nutrition research center on aging at tufts university     1 1.786%
31.laboratory of pharmaceutical biotechnology     1 1.786%
32.new york university school of medicine and va medical center     1 1.786%
33.queen elizabeth medical center     1 1.786%
34.school of agriculture & food science     1 1.786%
35.school of biochemistry and immunology     1 1.786%
36.school of biomedical and chemical sciences     1 1.786%
37.school of biotechnology     1 1.786%
38.school of chemistry & biochemistry     1 1.786%
39.school of medicine and     1 1.786%
40.school of pathology     1 1.786%
41.school of pathology and laboratory medicine (m502)     1 1.786%
42.school of veterinary science     1 1.786%
43.united states of america ; center for comparative genomics and bioinformatics     1 1.786%
44.usa [2] california national primate research center     1 1.786%
45.usa [2] center for comparative genomics and bioinformatics     1 1.786%
46.vu university medical center     1 1.786%




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