许培扬博客分享 http://blog.sciencenet.cn/u/xupeiyang 跟踪国际前沿 服务国内科研

博文

肝衰竭与长链脂酰CoA合成酶(ACSL1)的知识发现

已有 2991 次阅读 2016-10-25 17:58 |个人分类:知识发现|系统分类:科研笔记

这个知识发现平台可以免费使用,对科研人员信息检索、知识发现非常有用,可惜中国的科学家用的人很少。

我建议大家多用,你会有惊喜发现,祝你好运!

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/start.cgi


A-query: Liver Failure
C-query: ACSL1

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 21630 and can be accessed from the start page after you leave this session. There are 131 terms on the current B-list (45 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 21630 started Tue Oct 25 04:44:00 2016
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Liver Failure Tue Oct 25 04:45:01 2016

A query = Liver Failure started Tue Oct 25 04:45:03 2016
A query resulted in 50000 titles
C_query_raw: ACSL1 Tue Oct 25 04:45:58 2016

C: ACSL1 137

A: Liver Failure 58332

AC: ( Liver Failure ) AND ( ACSL1 ) 1

C_query_raw: ACSL1 Tue Oct 25 04:46:04 2016

C: ACSL1 137

A: Liver Failure 58332

AC: ( Liver Failure ) AND ( ACSL1 ) 1

C query = ACSL1 started Tue Oct 25 04:46:05 2016
C query resulted in 137 titles
A AND C query resulted in 1 titles
1066 B-terms ready on Tue Oct 25 04:46:14 2016

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
131 B-terms left after filter executed Tue Oct 25 04:46:54 2016

Viewed B-terms Tue Oct 25 04:49:31 2016
adiponectin

B-list on Tue Oct 25 04:58:11 2016
1 adiponectin
2 toll receptor
3 tlr4
4 mtor
5 ghrelin
6 target rapamycin
7 microrna
8 pparalpha
9 ppar
10 metabolic syndrome
11 single nucleotide polymorphism
12 autophagy
13 hepatic gene
14 toll
15 pten
16 cytokine production
17 gelsolin
18 leptin
19 genome wide
20 angiotensin receptor
21 peroxisome
22 cytochrome p450
23 p450
24 cytokine
25 dicer
26 atp binding
27 nucleotide sequence polymorphism
28 sp1
29 transcription factor
30 nash
31 ivf
32 interleukin
33 gene rat liver
34 differentially expressed gene
35 gsk-3beta
36 transporter
37 nucleotide sequence
38 promoter region
39 cpg
40 glucagon
41 analysis gene
42 egf
43 cd36
44 candidate gene
45 coa

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=21630


AB literature


B-term


BC literature


Liver Failure adiponectinACSL1
1: Impact of serum levels of interleukin-6 and adiponectin on all-cause, liver-related, and liver-unrelated mortality in chronic hepatitis C patients. 2015
Add to clipboard

2: Plasma Adiponectin Levels in Acute Liver Failure Patients Treated with Plasma Filtration with Dialysis and Plasma Exchange. 2015
Add to clipboard

3:Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease. 2014
Add to clipboard

4:Adiponectin and the cardiometabolic syndrome: an epidemiological perspective. 2014
Add to clipboard

5:Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. 2014
Add to clipboard

6: Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. 2013
Add to clipboard

7:Adiponectin, diabetes and ischemic heart failure: a challenging relationship. 2012
Add to clipboard

8: Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. 2010
Add to clipboard

9: Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. 2010
Add to clipboard

10: Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. 2007
Add to clipboard

11: Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice. 2006
Add to clipboard

12:[Adiponectin--adipocytokine with a broad clinical spectrum]. 2004
Add to clipboard

13: The role of the novel adipocyte-derived hormone adiponectin in human disease. 2003
Add to clipboard

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi



脂肪代谢基因通路  http://www.chinabaike.com/t/30340/2015/0201/3088677.html


   

(mouse)脂类主要包括脂肪、磷脂、鞘脂和胆固醇脂,其吸收代谢有两种情况: 中链、短链脂肪酸构成的甘油三酯乳化后即可吸收——>肠粘膜细胞内水解为脂肪酸及甘油——>门静脉入血。长链脂肪酸构成的甘油三酯在肠道分解为长链脂肪酸和甘油一酯,再吸收——>肠粘膜细胞内再合成甘油三酯,与载脂蛋白、胆固醇等结合成乳糜微粒——>淋巴入血甘油三脂代谢。

脂类相关代谢途径有以下四种:

· 甘油三脂代谢

· 磷脂代谢

· 胆固醇代谢

· 血浆脂蛋白代谢

脂肪代谢途径主要基因:

1、脂肪形成(adipogenesis)

2、调控基因(regulatory genes):

adipokines:adig (adipogenin), adipoq, cfd, lep, retn.(5)

hormones:agt, angpt2.(2)

enzymes:lipe, lpl.(2)

ppar gamma途径(ppar gamma targets):ipoq, cebpa, cfd, fabp4, fasn, irs2, klf15, pparg, ppargc1a (pgc-1a), retn, sirt3, srebf1.(12)

脂肪分化调控(adipogenesis regulation):

pro-adipogenesis: acacb, axin1, ccnd1, cdk4, cebpb, cebpd, dkk1, e2f1, fabp4, fasn, fgf1, fgf2, irs2, jun, lmna, rxra, sfrp1, sfrp5, slc2a4 (glut4), wnt5b.(20)

anti-adipogenesis: adrb2, cdkn1a, cdkn1b, ddit3, dlk1, foxo1, hes1, lrp5, ncor2, runx1t1, shh, sirt1, sirt2, taz, tcf7l2, tsc22d3, vdr, wnt1, wnt3a.(19)

pro-white adipose tissue: bmp2, bmp4, cebpa, egr2, fgf10, klf15, klf4.(7)

anti-white adipose tissue: gata2, gata3, klf2, klf3.(4)

pro-brown adipose tissue: bmp7, creb1, dio2, foxc2, insr, irs1, mapk14, nrf1, ppara, ppard, prdm16, sirt3, src, ucp1, wnt5a.(15)

anti-brown adipose tissue: ncoa2, nr0b2, nr1h3, rb1, twist1, wnt10b.(6)

2、脂肪酸代谢(fatty acid metabolism)

脂肪酸分解(fatty acid catabolism):

acetyl-coa transferases:acaa1a, acaa2, acat1, acat2.(4)

acyl-coa dehydrogenases:acad9, acad10, acad11, acadl, acadm, acads, acadsb, acadvl, ehhadh, gcdh.(10)

acyl-coa oxidases:acox1, acox2, acox3.(3)

acyl-coa synthetases:acsbg1, acsbg2, acsl1, acsl3, acsl4, acsl5, acsl6, acsm2, acsm3, acsm4, acsm5.(11)

acyl-coa thioesterases:acot2, acot3, acot6, acot7, acot8, acot9, acot12.(7)

carnitine transferases:cpt1a, cpt1b, cpt1c, cpt2, crat, crot.(6)

other:aldh2, decr1, decr2, echs1, hadha, mcee, mut, eci2, pecr, ppa1.(9)

脂肪酸运转(fatty acid transport):cpt1a, cpt1b, cpt1c, cpt2, crat, crot, fabp1, fabp2, fabp3, fabp4, fabp5, fabp6, slc27a1, slc27a2, slc27a3, slc27a4, slc27a5, slc27a6.(18)

脂肪酸合成调控(fatty acid biosynthesis regulation):prkaa1, prkaa2, prkab1, prkab2, prkaca, prkacb, prkag1, prkag2, prkag3.(9)

酮体生成(ketogenesis):bdh1, bdh2, hmgcl, hmgcs1, hmgcs2, oxct2a.(6)

甘油三酯分解代谢(triacylglycerol catabolism):gk2, gpd1, gpd2, gyk, lipe, lpl.(6)

脂蛋白信号和胆固醇代谢(lipoprotein signaling & cholesterol metabolism pcr array)

ldl receptors and associated proteins(低密度脂蛋白受体和相关蛋白)

ldl receptors:cxcl16, ldlr, lrp10, lrp12, lrp1b, lrp6, olr1, stab1, stab2, vldlr.(10)

ldl receptors associated proteins:lrpap1, pcsk9, snx17.(3)

ldl associated proteins:ankra2, apoa4, cdh13, colec12, crp, scarf1, sorl1.(7)

hdl associated proteins:apoa1, apod, apof, apol8.(5)

胆固醇转运cholesterol transport:

cholesterol transporters:abca1, abcg1, apoa1, apoe, stard3.(5)

cholesterol efflux:abca1, abcg1, apoa1, apoa4, apoe.(4)

reverse cholesterol transport:abca1, apoa1, apoa2, apoa4, apoe, lcat.(6)

other genes involved in cholesterol transport:apob, ldlr, npc1l1, osbpl5.(4)

胆固醇代谢cholesterol metabolism:

cholesterol absorption:cel, ldlr, npc1l1.(3)

cholesterol catabolism:akr1d1, apoe, cel, cyp39a1, cyp46a1, cyp7a1, scarf1, snx17, trerf1.(9)

cholesterol homeostasis:abca1, abcg1, angptl3, apoa1, apoa2, apoa4, apoe, lcat, ldlr, ldlrap1, pcsk9.(11)

cholesterol biosynthesis:acaa2, cnbp, cyb5r3 (dia1), cyp51, dhcr24, dhcr7, ebp, fdft1, fdps, hmgcr, hmgcs1, hmgcs2, idi1, idi2, mvd, mvk, npc1l1, nsdhl, pmvk, prkaa1, prkaa2, prkag2, tm7sf2.(23)

other genes involved in cholesterol metabolism:abca2, apob, apoc3, apof, apol8, cyp11a1, cyp7b1, cela3b, hdlbp, il4, insig1, insig2, lep, lipe, mbtps1, nr0b2, nr1h4, osbpl1a, osbpl5, ppard, scap, soat1, soat2, sorl1, srebf1, srebf2, stard3, vldlr.(28)




http://blog.sciencenet.cn/blog-280034-1010807.html

上一篇:活到老 学到老
下一篇:韩春雨论文《自然·生物技术》最新回复 10月22日

0

该博文允许注册用户评论 请点击登录 评论 (0 个评论)

数据加载中...

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2020-4-8 05:26

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部