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2016拉斯克奖得主William G. Kaelin教授的科学贡献

已有 3660 次阅读 2016-9-14 09:22 |个人分类:科学名人|系统分类:观点评述


       今年的“拉斯克基础医学奖”授予三位在人以及大多数动物细胞感知、适应氧气的变化机制方面做出杰出贡献的医学研究者。他们分别是来自哈佛医学院Dana-Farber癌症研究所的William G. Kaelin、英国牛津大学弗朗西斯·克里克研究所(Francis Crick Institute)的Peter J. Ratcliffe以及约翰霍普金斯医学院(Johns Hopkins University School of Medicine)的Gregg Semenza。http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=1002833

所在机构:Dana Farber Cancer Institute
发表数:218
引用数:26626


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年份年份趋势图
记录数
占%
01.2016     7 6.087%
02.2014     7 6.087%
03.2013     7 6.087%
04.2011     6 5.217%
05.2010     9 7.826%
06.2009     8 6.957%
07.2008     9 7.826%
08.2007     11 9.565%
09.2006     7 6.087%
10.2005     9 7.826%
11.2015     5 4.348%
12.2012     5 4.348%
13.2011     6 5.217%
14.2006     7 6.087%
期刊期刊分区中科院期刊分区
记录数
占%
01.cancer cell     16 13.913%
02.proc natl acad sci u s a     8 6.957%
03.genes dev     6 5.217%
04.nature     6 5.217%
05.science     6 5.217%
06.cell     5 4.348%
07.clin cancer res     5 4.348%
08.mol cell biol     5 4.348%
09.mol cell     4 3.478%
10.j clin invest     3 2.609%
11.methods enzymol     3 2.609%
12.nat rev cancer     3 2.609%
13.blood     2 1.739%
14.cancer     2 1.739%
15.cancer res     2 1.739%
16.embo j     2 1.739%
17.nat cell biol     2 1.739%
18.nat genet     2 1.739%
19.am j pathol     1 0.870%
20.ann n y acad sci     1 0.870%
21.annu rev biochem     1 0.870%
22.annu rev pathol     1 0.870%
23.biochem biophys res commun     1 0.870%
24.cancer biol ther     1 0.870%
25.cancer discov     1 0.870%
26.cell cycle     1 0.870%
27.cell metab     1 0.870%
28.cell res     1 0.870%
29.circulation     1 0.870%
30.curr opin genet dev     1 0.870%
31.curr opin pharmacol     1 0.870%
32.embo rep     1 0.870%
33.endocr pathol     1 0.870%
34.endocr relat cancer     1 0.870%
35.genome med     1 0.870%
36.genome res     1 0.870%
37.hematol oncol clin north am     1 0.870%
38.j am soc nephrol     1 0.870%
39.j biol chem     1 0.870%
40.j clin oncol     1 0.870%
41.methods mol biol     1 0.870%
42.mol cancer res     1 0.870%
43.mol imaging     1 0.870%
44.n engl j med     1 0.870%
45.nat med     1 0.870%
46.neoplasia     1 0.870%
47.ophthalmology     1 0.870%
48.plos biol     1 0.870%
49.sci stke     1 0.870%
50.semin cancer biol     1 0.870%
国家国家分布图
记录数
占%
01.美国     98 85.217%
02.中国大陆     3 2.609%
03.芬兰     3 2.609%
04.加拿大     2 1.739%
05.印度     1 0.870%
06.日本     1 0.870%
07.英国     1 0.870%
08.荷兰     1 0.870%
09.韩国     1 0.870%
大陆城市境外城市
记录数
占%
01.美国波士顿     83 72.174%
02.chevy chase     10 8.696%
03.美国北卡罗来纳州教堂山镇     5 4.348%
04.美国纽约     5 4.348%
05.马萨诸塞州剑桥市     5 4.348%
06.美国休斯敦     4 3.478%
07.美国安德森(安德森癌症中心)     4 3.478%
08.美国麻省剑桥市     4 3.478%
09.芬兰奥卢     4 3.478%
10.brookline     3 2.609%
11.kettering.us     3 2.609%
12.farber     2 1.739%
13.piscataway     2 1.739%
14.美国旧金山     2 1.739%
15.美国芝加哥     2 1.739%
16.albany .ny     1 0.870%
17.birmingham.uk     1 0.870%
18.blackpool     1 0.870%
19.boulevard     1 0.870%
20.brunswick     1 0.870%
21.canada.alexander     1 0.870%
22.fort smith     1 0.870%
23.framingham     1 0.870%
24.gurgaon     1 0.870%
25.hughes     1 0.870%
26.jefferson     1 0.870%
27.koch     1 0.870%
28.la jolla     1 0.870%
29.mount sinai     1 0.870%
30.new brunswick .ca     1 0.870%
31.old bridge     1 0.870%
32.port arthur     1 0.870%
33.potrero     1 0.870%
34.smith.canada     1 0.870%
35.university place     1 0.870%
36.albany.ca     1 0.870%
37.加拿大多伦多     1 0.870%
38.加拿大温哥华     1 0.870%
39.印度斯利那加     1 0.870%
40.日本京都     1 0.870%
41.美国华盛顿州温哥华     1 0.870%
42.美国圣迭戈     1 0.870%
43.美国巴尔的摩霍普金斯     1 0.870%
44.美国巴的摩尔     1 0.870%
45.美国帕萨迪纳     1 0.870%
46.美国弗雷德里克     1 0.870%
47.美国洛杉矶     1 0.870%
48.美国盐湖城     1 0.870%
49.美国米德尔塞克斯     1 0.870%
50.美国纽黑文     1 0.870%
大陆作者作者与主题词全部作者作者邮件
记录数
占%
01.Kaelin WG     113 98.261%
02.Signoretti S     13 11.304%
03.Kim WY     10 8.696%
04.Minamishima YA     9 7.826%
05.Zhang Q     9 7.826%
06.Moslehi J     8 6.957%
07.Wei W     8 6.957%
08.Kondo K     7 6.087%
09.Yan Q     7 6.087%
10.Koivunen P     6 5.217%
11.Li L     6 5.217%
12.Schlisio S     6 5.217%
13.Bronson RT     5 4.348%
14.Chakraborty AA     5 4.348%
15.Geisen C     5 4.348%
16.Linehan WM     5 4.348%
17.Meyerson M     5 4.348%
18.Nakamura E     5 4.348%
19.Safran M     5 4.348%
20.Yang H     5 4.348%
21.Zhang GJ     5 4.348%
22.George DJ     4 3.478%
23.Losman JA     4 3.478%
24.Lu G     4 3.478%
25.Ohh M     4 3.478%
26.Atkins MB     3 2.609%
27.Benevolenskaya EV     3 2.609%
28.Beroukhim R     3 2.609%
29.Bommi-Reddy A     3 2.609%
30.Carter BD     3 2.609%
31.DePinho RA     3 2.609%
32.Ebert BL     3 2.609%
33.Figlin RA     3 2.609%
34.Hahn WC     3 2.609%
35.Ivan M     3 2.609%
36.King L     3 2.609%
37.Klco JM     3 2.609%
38.Kung AL     3 2.609%
39.Lee S     3 2.609%
40.Liberzon E     3 2.609%
41.Liu J     3 2.609%
42.Liu W     3 2.609%
43.Olenchock BA     3 2.609%
44.Padera RF     3 2.609%
45.Richardson AL     3 2.609%
46.Root DE     3 2.609%
47.Shen C     3 2.609%
48.Vander Heiden MG     3 2.609%
49.Wong KK     3 2.609%
50.Zhang J     3 2.609%
大陆机构第一作者机构合著机构境外机构
记录数
占%
01.美国丹那法伯肿瘤研究所     70 60.870%
02.哈佛医学院     58 50.435%
03.布莱根妇女医院     49 42.609%
04.霍华德·休斯医学研究所     31 26.957%
05.北卡罗来纳大学     6 5.217%
06.贝斯以色列女执事医疗中心     5 4.348%
07.dana-farber cancer institute and harvard medical school     4 3.478%
08.北卡罗来纳大学教堂山分校     3 2.609%
09.奥卢大学     3 2.609%
10.德克萨斯大学     3 2.609%
正在加载中...
主题词主题词搭配主题词与主题词
记录数
占%
01.von hippel-lindau tumor suppressor protein     37 32.174%
02.kidney neoplasms     26 22.609%
03.tumor suppressor proteins     26 22.609%
04.transcription factors     24 20.870%
05.carcinoma, renal cell     23 20.000%
06.hypoxia-inducible factor 1, alpha subunit     21 18.261%
07.ubiquitin-protein ligases     21 18.261%
08.mutation     20 17.391%
09.gene expression regulation, neoplastic     18 15.652%
10.cell line, tumor     16 13.913%
11.procollagen-proline dioxygenase     16 13.913%
12.dna-binding proteins     15 13.043%
13.hypoxia-inducible factor 1     15 13.043%
14.neoplasms     14 12.174%
15.von hippel-lindau disease     14 12.174%
16.nuclear proteins     13 11.304%
17.oxygen     12 10.435%
18.molecular sequence data     11 9.565%
19.rna, small interfering     11 9.565%
20.signal transduction     11 9.565%
21.base sequence     10 8.696%
22.basic helix-loop-helix transcription factors     10 8.696%
23.cells, cultured     10 8.696%
24.ligases     10 8.696%
25.antineoplastic agents     9 7.826%
26.genes, tumor suppressor     9 7.826%
27.hydroxylation     9 7.826%
28.mice, nude     9 7.826%
29.models, biological     9 7.826%
30.protein binding     9 7.826%
31.amino acid sequence     8 6.957%
32.cell proliferation     8 6.957%
33.gene expression regulation     8 6.957%
34.hela cells     8 6.957%
35.phenotype     8 6.957%
36.anoxia     7 6.087%
37.apoptosis     7 6.087%
38.cell cycle proteins     7 6.087%
39.cell line     7 6.087%
40.dioxygenases     7 6.087%
41.gene expression profiling     7 6.087%
42.liver     7 6.087%
43.mice, inbred c57bl     7 6.087%
44.cell hypoxia     6 5.217%
45.cell transformation, neoplastic     6 5.217%
46.mice, knockout     6 5.217%
47.mice, transgenic     6 5.217%
48.pheochromocytoma     6 5.217%
49.retinoblastoma protein     6 5.217%
50.rna interference     6 5.217%
Substance化学药中药
记录数
占%
01.von hippel-lindau tumor suppressor protein     37 32.174%
02.tumor suppressor proteins     26 22.609%
03.vhl protein, human     25 21.739%
04.transcription factors     24 20.870%
05.hypoxia-inducible factor 1, alpha subunit     21 18.261%
06.ubiquitin-protein ligases     21 18.261%
07.procollagen-proline dioxygenase     16 13.913%
08.dna-binding proteins     15 13.043%
09.hypoxia-inducible factor 1     15 13.043%
10.hif1a protein, human     13 11.304%
11.nuclear proteins     13 11.304%
12.oxygen     12 10.435%
13.rna, small interfering     11 9.565%
14.basic helix-loop-helix transcription factors     10 8.696%
15.ligases     10 8.696%
16.antineoplastic agents     9 7.826%
17.endothelial pas domain-containing protein 1     9 7.826%
18.cell cycle proteins     7 6.087%
19.dioxygenases     7 6.087%
20.egln1 protein, mouse     7 6.087%
21.retinoblastoma protein     6 5.217%
22.vascular endothelial growth factor a     6 5.217%
23.enzyme inhibitors     5 4.348%
24.hif1a protein, mouse     5 4.348%
25.proline     5 4.348%
26.ubiquitin     5 4.348%
27.dna primers     4 3.478%
28.egln1 protein, human     4 3.478%
29.egln2 protein, human     4 3.478%
30.egln3 protein, human     4 3.478%
31.elongin     4 3.478%
32.hypoxia-inducible factor-proline dioxygenases     4 3.478%
33.immediate-early proteins     4 3.478%
34.phd3 protein, mouse     4 3.478%
35.proteins     4 3.478%
36.proto-oncogene proteins     4 3.478%
37.repressor proteins     4 3.478%
38.succinate dehydrogenase     4 3.478%
39.tor serine-threonine kinases     4 3.478%
40.alpha-hydroxyglutarate     3 2.609%
41.asparagine     3 2.609%
42.cul2 protein, human     3 2.609%
43.cullin proteins     3 2.609%
44.erythropoietin     3 2.609%
45.glutarates     3 2.609%
46.isocitrate dehydrogenase     3 2.609%
47.luciferases     3 2.609%
48.protein kinases     3 2.609%
49.recombinant fusion proteins     3 2.609%
50.rna, messenger     3 2.609%
疾病症状治疗方法物种解剖食品
记录数
占%
01.肿瘤     86 74.783%
02.男性泌尿生殖器疾病     36 31.304%
03.癌,肿瘤     36 31.304%
04.女性泌尿生殖器疾病     35 30.435%
05.女性泌尿生殖器疾病和妊娠并发症     35 30.435%
06.泌尿系疾病     35 30.435%
07.肾疾病     35 30.435%
08.泌尿生殖系统癌     34 29.565%
09.肾肿瘤     34 29.565%
10.泌尿系癌     33 28.696%
11.腺和上皮癌     30 26.087%
12.腺癌     27 23.478%
13.肾细胞癌     24 20.870%
14.心血管疾病     19 16.522%
15.von hipple-lindau综合征,脑视网膜血管瘤病     18 15.652%
16.细胞转化, 肿瘤     18 15.652%
17.神经系统疾病     16 13.913%
18.血管疾病     16 13.913%
19.神经皮肤综合征     15 13.043%
20.血管瘤病,多发性血管瘤     14 12.174%
21.嗜铬细胞瘤     9 7.826%
22.癌形成过程     9 7.826%
23.副神经节瘤     8 6.957%
24.生殖细胞和胚胎性癌     8 6.957%
25.神经外胚瘤     8 6.957%
26.神经组织癌     8 6.957%
27.血管母细胞瘤     8 6.957%
28.神经内分泌瘤     7 6.087%
29.血液和淋巴系统疾病     7 6.087%
30.视网膜母细胞瘤     7 6.087%
31.透明细胞腺癌     7 6.087%
32.血液病     6 5.217%
33.遗传性癌综合征     6 5.217%
34.内分泌系统疾病     5 4.348%
35.内分泌腺癌     5 4.348%
36.心肌梗塞     5 4.348%
37.肾上腺疾病     5 4.348%
38.肾上腺癌     5 4.348%
39.乳腺癌     4 3.478%
40.心肌疾病     4 3.478%
41.心脏病     4 3.478%
42.扩张型心肌病     4 3.478%
43.红细胞增多症     4 3.478%
44.贫血     4 3.478%
45.dna损伤     3 2.609%
46.中风     3 2.609%
47.心脏扩大     3 2.609%
48.白血病     3 2.609%
49.皮肤与结缔组织疾病     3 2.609%
50.皮肤疾病     3 2.609%
科室学科
记录数
占%
01.生物学     3 2.609%
02.肿瘤学     3 2.609%
03.化学     2 1.739%
04.妇产科学     2 1.739%
05.病理学与病理生理学     2 1.739%
06.临床检验诊断学     1 0.870%
07.免疫学     1 0.870%
08.医学遗传学     1 0.870%
09.心血管病学     1 0.870%
10.普通外科学     1 0.870%
11.流行病与卫生统计学     1 0.870%
12.生理学     1 0.870%
13.病原生物学     1 0.870%
14.药学     1 0.870%
15.预防医学     1 0.870%





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