与前列腺癌发生有关的20个临检基因和84个与发展和预后有关的基因

前列腺癌基因临检：

AKT1、APC、ARID1A、ATM、BRCA1、BRCA2、CDKN2A、CTNNB1、EGFR、EZH2、HRAS、IDH1、KDM6A、MTOR、PIK3CA、PIK3R1、PTEN、RB1、SRC和TP53

其中，APC、BRCA1、BRCA2、TP53、PTEN、RB1等为肿瘤抑制基因

与前列腺癌发展预后有关的84个基因（相应基因的属性请点击该基因的内链接）

Differentially Methylated Promoters

差异性启动子甲基化修饰的基因

APC, AR, CAV1, CCNA1, CDH1 (E-Cadherin), CDKN2A (p16INK4a), DKK3, DLC1, EDNRB, GPX3, GSTP1, MGMT (AGT), MSX1, PDLIM4 (RIL), PTGS2 (COX2), RARB, RASSF1, SFRP1, SLC5A8, TIMP2, TNFRSF10D, ZNF185.

Up-Regulated in Prostate Cancer

上调表达的基因

ARNTL (BMAL1), CAMSAP1, DDX11, ECT2, ETV1, HAL, IGFBP5, KLK3, MTO1, PDPK1, RBM39, SOCS3, SOX4, SUPT7L.

Down-Regulated in Prostate Cancer

下调表达的基因

CCND2, CLN3, GCA, IGF1, LGALS4, LOXL1, PPP2R1B, SFRP1, SLC5A8, TFPI2, USP5.

Metastatic Potential

转移潜能相关基因

CREB1, KLHL13, MAX, NDRG3, PES1, SEPT7, SCAF11 (SFRS2IP).

Androgen Receptor Signaling

雄性激素受体信号传导有关的基因

AR, CAV1, CCND1, DAXX, EGFR (ERBB1), FOXO1, GNRH1, IGF1, IL6, NFKB1, NRIP1, PTEN, SHBG, TGFB1I1, TIMP2, TIMP3, VEGFA.

AKT & PI3 Kinase Signaling

AKT和PI3激酶信号传导

AKT1, AR, BCL2, CCND1, CCND2, CDH1 (E-Cadherin), CDKN2A (p16INK4a), EGFR (ERBB1), FOXO1, GNRH1, IGF1, IL6, MAPK1 (ERK2), NFKB1, PDPK1, PTEN, TIMP2, TIMP3, TNFRSF10D, TP53 (p53), VEGFA.

PTEN Signaling

PTEN信号传导

AKT1, EGFR (ERBB1), GNRH1, IGF1, IL6, MAPK1 (ERK2), PDPK1, PTEN, TIMP2, TIMP3, TP53 (p53), VEGFA.

Apoptosis

细胞凋亡

BCL2, CASP3, CDKN2A (p16INK4a), EGFR (ERBB1), ETV1, GNRH1, IGF1, IL6, MAPK1 (ERK2), NFKB1, PTEN, TIMP2, TIMP3, TP53 (p53), VEGFA.

Cell Cycle

细胞周期

APC, BCL2, CASP3, CAV2, CCNA1, CCND1, CCND2, CDKN2A (p16INK4a), EGFR (ERBB1), IGF1, PPP2R1B, PTEN, PTGS1 (COX1), PTGS2 (COX2), TP53 (p53).

Transcription Factors

转录因子

AR, ARNTL (BMAL1), CDKN2A (p16INK4a), CREB1, DAXX, EGR3, ERG, ETV1, FOXO1, MAX, MSX1, NFKB1, NKX3-1, NRIP1, RARB, RBM39, SOX4, SREBF1, SUPT7L, TP53 (p53).

Fatty Acid Metabolism

脂肪酸代谢

ACACA, CAMKK1, FASN, HMGCR, IGF1, PRKAB1, SREBF1, STK11 (LKB1).

Other Prostate Cancer Genes

其他与前列腺癌有关的基因

MKI67, TMPRSS2.