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姜黄素抗癌作用研究相关文献(PubMed数据库统计结果)

已有 4799 次阅读 2014-9-25 10:15 |个人分类:新药动态|系统分类:论文交流|关键词:姜黄素,抗癌药,综述| 综述, 抗癌药, 姜黄素

姜黄素抗癌作用研究相关文献

——PubMed数据库统计结果

诸平

1 姜黄素(Curcumin)研究文献变化


    姜黄素化学结构式

1970~2014年9月下旬PubMed数据库收录了相关研究论文近7000篇,具体年度收录量见图1:其中有关“Anticarcinogenic Agents(抗致癌药物)”近240篇;“Chemoprevention(化学预防)”近190篇。化学预防是指利用化学复合物预防恶性肿瘤的发生, 作为癌症治疗新方法之一, 正受到广泛重视大肠癌以及肺癌前列腺癌乳腺癌等, 在确定了癌前病变的疾病或已确定了致病基因的疾病中, 可以选定为高危组, 并进行各种化学预防研究                         图1 1970~2014年PubMed数据库收录姜黄素研究文献的变化

2 姜黄素与抗癌研究文献变化

姜黄素与癌症(Curcumin, cancers)结合作为检索词,通过PubMed数据库可以检索到相关文献近1800篇;其中以美国研究最多604篇,其次是中国(包括台湾106篇)385篇,印度位于第三(176篇),其余均在100篇以下。年度变化见图2.

图2 1983~2014年姜黄素与抗癌研究文献变化

3 综述性文献的统计结果

姜黄素与抗癌研究的综述性文献有400余篇,其年度变化见图3.


图3 姜黄素与抗癌作用的综述性研究文献变化

下面列举几篇综述性研究论文,供大家参考:

Aliye Aras, Abdur Rehman Khokhar, MuhammadZahid Qureshiet al. TargetingCancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on FlyingCarpets. Asian Pac J Cancer Prev, 2014, 15(9): 3865-3871.

http://www.apocpcontrol.org/paper_file/issue_abs/Volume15_No9/3865-3871%202.23%20Aliye%20Aras%20(MINI-REVIEW).pdf

 

Sana Afreen, Mir S Adil, MohammedNassir M, Muniba Suad, Sidhra Fatima. Curcumin and its promising role in theprevention of cancer. Int. Res. J. Pharm. 2013; 4(12):1-3 http://dx.doi.org/10.7897/2230-8407.041201

 

Turmeric & Cancer

http://greenhealthmatters.com/wp-content/uploads/2014/08/Anti-Cancer-Foods-2-Turmeric.pdf

 

Noor Hasima, Bharat B Aggarwal. Cancer-linked targets modulated by curcumin. Int J Biochem MolBiol, 2012, 3(4): 328-351. http://www.ijbmb.org/files/ijbmb1209004.pdf

 

DarveshA S, AggarwalB B, BishayeeA. Curcuminand liver cancer: a review. Curr Pharm Biotechnol. 201213(1): 218-228.

 

Role of Curcumin in Cancer Therapy. CurrProbl Cancer, 2007, 31: 243-305.参考了289篇参考文献,综述长达63页,详见:

http://www.elsevier.com/__data/assets/pdf_file/0006/115719/current-problems-in-cancer-article-1.pdf

 

Reason Wilken, Mysore S Veena, Marilene B Wang, et al. Cucurmin:A review of anti-cancer properties and therapeutic activity in head and neck squamouscell carcinoma[J]. Mol Cancer, 2011, 10: 12. http://www.molecular-cancer.com/content/pdf/1476-4598-10-12.pdf

4 综述性论文作者关系图

其中美国德克萨斯大学(University of Texas M. D. Anderson Cancer Center)的Aggarwal, B B,先后曾经撰写过20余篇有关姜黄素与抗癌作用的综述性研究文献,具体作者关系图见图4.

图4 综述作者关系图

5 Aggarwal, B B的部分论文摘录

Recent developments in delivery, bioavailability, absorption andmetabolism of curcumin: the golden pigment from golden spice.
Authors: Prasad, Sahdeo, et.al. .
Journal: Cancer research and treatment : official journal of Korean Cancer Association (Cancer Res Treat), Vol. 46 (1): 2-18, 2014.
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA..
Related Products: order online
Targeting proteasomal pathways by dietary curcumin for cancerprevention and treatment.
Authors: Hasima, Noor, et.al. .
Journal: Current medicinal chemistry (Curr Med Chem), Vol. 21 (14): 1583-94, 2014 .
In this review, we discuss in detail how modulation of these targets by curcumin is linked to prevention and treatment ofcancer.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States. aggarwal@mdanderson.org..
Chemopreventive and chemotherapeutic potential of curcumin in breastcancer.
Authors: Sinha, Dona, et.al. .
Journal: Current drug targets (Curr Drug Targets), Vol. 13 (14): 1799-819, 2012 .
The current review critically analyzes various aspects of curcumin-related research conducted for molecular understanding of its efficacy in in vitro and in vivo models of breast cancer.
Affiliation: Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India. dona.sinha@cnci.org.in.
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Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents.
Authors: Gupta, Subash C, et.al. .
Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (maywood)), Vol. 236 (6): 658-71, 2011 .
We will also discuss how nutritional agents such as curcumin, genistein, resveratrol, epigallocatechin gallate and lycopene can modulate inflammatory pathways and thereby reduce cancer-related symptoms in patients.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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Epigenetic changes induced by curcumin and other natural compounds.
Authors: Reuter, Simone, et.al. .
Journal: Genes & nutrition (Genes Nutr), Vol. 6 (2): 93-108, 2011 .
This review summarizes current knowledge about the effect of curcumin on the regulation of histone deacetylases,histone acetyltransferases, DNA methyltransferase I, and miRNAs.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA..
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Curcumin and liver cancer: a review.
Authors: Darvesh, Altaf S, et.al. .
Journal: Current pharmaceutical biotechnology (Curr Pharm Biotechnol), Vol. 13 (1): 218-28, 2012 .
This review also discusses potential challenges involved in the use of curcumin in HCC, such as bioavailability,pharmacokinetics, drug delivery as well as paucity of clinical studies.
Affiliation: Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA..
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Curcumin, the golden spice from Indian saffron, is a chemosensitizer andradiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Authors: Goel, Ajay, et.al. .
Journal: Nutrition and cancer (Nutr Cancer), Vol. 62 (7): 919-30, 2010 .
Similar studies have also revealed that this agent can sensitize a variety of tumors to gamma radiation including glioma,neuroblastoma, cervical carcinoma, epidermal carcinoma, prostate cancer, and colon cancer.
Affiliation: Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA. .
Targeting inflammation-induced obesity and metabolic diseases bycurcumin and other nutraceuticals.
Journal: Annual review of nutrition (Annu Rev Nutr), Vol. 30, 2010 .
Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. aggarwal@mdanderson.org.
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Authors: Aggarwal, Bharat B, et.al. .
Journal: Trends in pharmacological sciences (Trends Pharmacol Sci), Vol. 30 (2): 85-94, 2009 .
Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such ascyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6).
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. aggarwal@mdanderson.org.
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.
Authors: Reuter, Simone, et.al. .
Journal: Biochemical pharmacology (Biochem Pharmacol), Vol. 76 (11): 1340-51, 2008 .
This article reviews the main effects of curcumin on the different apoptotic signaling pathways involved in curcumin-induced apoptosis of cancer cells, including the intrinsic and extrinsic apoptosis pathways, the NF-kappaB-mediated pathway as well as the PI3K/Akt signaling pathway.
Affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9 rue Edward Steichen, L-2540 Luxembourg, Luxembourg..
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic,autoimmune and neoplastic diseases.
Authors: Aggarwal, Bharat B, et.al. .
Journal: The international journal of biochemistry & cell biology (Int J Biochem Cell B), Vol. 41 (1): 40-59, 2009 .
In the current review, we provide evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases.
Affiliation: Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. aggarwal@mdanderson.org.
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Potential of spice-derived phytochemicals for cancer prevention.
Authors: Aggarwal, Bharat B, et.al. .
Journal: Planta medica (Planta Med), Vol. 74 (13): 1560-9, 2008 .
For instance, the potential of turmeric (curcumin), red chilli (capsaicin), cloves (eugenol), ginger (zerumbone), fennel(anethole), kokum (gambogic acid), fenugreek (diosgenin), and black cumin (thymoquinone) in cancer prevention has been established.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. aggarwal@mdanderson.org.
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Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Journal: Cancer letters (Cancer Lett), Vol. 269 (2): 199-225, 2008 .
These aspects of curcumin are discussed further in detail in this review.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA..
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Multi-targeted therapy by curcumin: how spicy is it?
Authors: Goel, Ajay, et.al. .
Journal: Molecular nutrition & food research (Mol Nutr Food Res), Vol. 52 (9): 1010-30, 2008 .
The present article reviews the key molecular mechanisms of curcumin action and compares this to some of the single-targeted therapies currently available for human cancer.
Affiliation: Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA..
Bioavailability of curcumin: problems and promises.
Authors: Anand, Preetha, et.al. .
Journal: Molecular pharmaceutics (Mol Pharm), Vol. 4 (6): 807-18, 2007 Nov-Dec .
Despite the lower bioavailability, therapeutic efficacy of curcumin against various human diseases, including cancer,cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohn's disease, has been documented.
Affiliation: Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA..
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Curcumin as "Curecumin": from kitchen to clinic.
Authors: Goel, Ajay, et.al. .
Journal: Biochemical pharmacology (Biochem Pharmacol), Vol. 75 (4): 787-809, 2008 .
Other clinical trials suggest a potential therapeutic role for curcumin in diseases such as familial adenomatous polyposis, inflammatory bowel disease, ulcerative colitis, colon cancer, pancreatic cancer, hypercholesteremia,atherosclerosis, pancreatitis, psoriasis, chronic anterior uveitis and arthritis.
Affiliation: Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States..
Role of curcumin in cancer therapy.
Authors: Shishodia, Shishir, et.al. .
Journal: Current problems in cancer (Curr Prob Cancer), Vol. 31 (4): 243-305, 2007 Jul-Aug .
No Abstract available.
Affiliation: Department of Biology, Texas Southern University, Houston, Texas, USA. .
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Curcumin: the Indian solid gold.
Authors: Aggarwal, Bharat B, et.al. .
Journal: Advances in experimental medicine and biology (Adv Exp Med Biol), Vol. 595, 2007 .
Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticanceractivities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. aggarwal@mdanderson.org.
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Authors: Aggarwal, Bharat B, et.al. .
Journal: Annals of the New York Academy of Sciences (Ann Ny Acad Sci), Vol. 1091, 2006 .
Its role in cancer is indicated by numerous avenues of evidence, including the following: STAT3 is constitutively active intumor cells; STAT3 is activated by growth factors (e.g., EGF, TGF-alpha, IL-6, hepatocyte growth factor) and oncogenickinases (e.g., Src); STAT3 regulates the expression of genes that mediate proliferation (e.g., c-myc and cyclin D1), suppress apoptosis (e.g., Bcl-x(L) and survivin), or promote angiogenesis (e.g, VEGF); STAT3 activation has been linked with chemoresistance and radioresistance; and chemopreventive agents have been shown to suppress STAT3activation.
Affiliation: Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. aggarwal@mdanderson.org.
"Spicing up" of the immune system by curcumin.
Authors: Jagetia, Ganesh Chandra, et.al. .
Journal: Journal of clinical immunology (J Clin Immunol), Vol. 27 (1): 19-35, 2007 .
This suggests that curcumin's reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease,Alzheimer's disease, diabetes, and cancer might be due in part to its ability to modulate the immune system.
Affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA..

Antibodies OnlineInterleukin 2 (IL2), Tumor Necrosis Factor (TNF), Interleukin 1 Receptor Like 2 (IL6)...

更多信息请浏览:http://www.gopubmed.com/ 


Here are the studies on Cancer and Turmeric:

 Turmeric stops cancer from starting: Preclinical cancer research using curcumin has shown it inhibits carcinogenesis in a number of cancer types, including colorectal, pancreatic, gastric, prostate, hepatic, breast, and oral cancers, and leukemia, and at various stages of carcinogenesis.5


 Turmeric stopped cancer from growing - Turmeric also helps to prevent angiogenesis – in other words, it prevents the tumor from creating its own blood supply to help the tumor grow even bigger.6

 Turmeric stopped cancer from spreading - Turmeric stops metastasis – or the spread of cancer cells in certain cancers.7

 Turmeric kills cancer cells - Turmeric also encourages cancer cells to commit suicide – apoptosis.8

 There are current trials on turmeric and cancer to see if it can be used as a drug - There are currently at least nine ongoing trials investigating the effects of turmeric and curcumin as a cancer therapy.9

 Turmeric can be used with Chemo if you are having chemo - Turmeric can be used in conjunction with chemotherapy. In fact, curcumin has been found to enhance certain types of chemotherapy and radiation and is now being used as a complementary therapy during chemo by some clinics.10

 Turmeric can make chemo more effective - Turmeric has been found to enhance the effects of chemotherapy in certain cancers.11

 Turmeric makes chemo more effective - Another study found curcumin made certain tumors more susceptible to the chemo so the chemo killed more of the tumor.12

 Turmeric prevents certain cancers - Other studies have shown curcumin helps to suppress certain cancers.13

 Turmeric has been used on the following cancers - Turmeric studies have shown that curcumin has been effective in:

1. Bowel Cancer14 15

2. Throat and esophageal cancer16

3. Colorectal cancer17

4. Breast cancer18 19

5. Cervical cancer20 21

6. Lung cancer22 23 24

7. Pancreatic cancer25

8. Prostate cancer26 27

9. Skin cancer28


更多信息请浏览:http://greenhealthmatters.com/wp-content/uploads/2014/08/Anti-Cancer-Foods-2-Turmeric.pdf

姜黄素的人工合成:

参考文献No.54544
标题:Curcumin
作者:Scrimal, R.C.
来源:Drugs Fut 1987,12(4),331
合成路线图解说明:

Synthesis of curcumin was first described by Lampe et al. In our laboratory curcumin has been synthesized by condensing vanillin (I) and acetyl acetone (II) in a medium of ethyl acetate using tributylborate as boron complex to avoid Knoevenagel condensation at C-3 of acetyl acetone. Curcumin is isolated from the reaction mixture by acidification and extraction with ethyl acetate. The organic layers are washed until neutral, dried and the solvent is removed. purified by chromatography over silica gel using ether/petroleum ether as the solvent.

参考文献No.589471
标题:Labelled compounds of interest as antitumour agents - VII. [H-2]- and [C-14]-curcumin
作者:Threadgill, M.D.; Parveen, I.
来源:J Label Compd Radiopharm 2000,43(9),883
合成路线图解说明:

The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 2H-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.

合成路线图解说明:

The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 14C-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.




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