Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent ...
…, M Narita, T Ichisaka, K Tomoda, S Yamanaka - cell, 2007 - repository.kulib.kyoto-u.ac.jp
抄録: Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient-and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from ...
K Okita, T Ichisaka, S Yamanaka - Nature, 2007 - nature.com
Abstract We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression. These induced ...
…, K Takahashi, M Maruyama, M Maeda, S Yamanaka - cell, 2003 - ccsu.edu
... Figure 4. Targeted Disruption of the Mouse nanog Gene (A) Structures of the mouse nanog gene, targeting constructs, and correctly targeted loci. Positions of the probe and ScaI recognition sites (S) used for Southern blot were shown. ... scribed (Yamanaka et al., 2000, 1998). ...
…, M Makishima, T Funahashi, S Yamanaka… - Science …, 2005 - stke.sciencemag.org
Abstract: Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in ...
…, K Okita, Y Mochiduki, N Takizawa, S Yamanaka - Nature …, 2007 - nature.com
Abstract Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of four transcription factors: ...