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哈维·J·阿尔特(Harvey J. Alter)近十年来的部分研究成果

已有 2974 次阅读 2020-10-6 21:55 |个人分类:新观察|系统分类:人物纪事| 哈维·J·阿尔特, 长跑运动员

哈维·J·阿尔特(Harvey J. Alter)近十年来的部分研究成果

诸平

王庆浩博主在《2020诺贝尔生理医学奖原创探索之旅》博文中指出:1970年哈维·J·阿尔特(Harvey J. Alter与其同事开始研究输血患者的肝炎发病率,1972年他们在Ann Intern Med发表了研究结果。3年之后的1975年Harvey J. Alter与其同事在N Engl J Med发表论文,报告了输血相关性肝炎不是由于甲肝和乙肝引起的。同年Harvey J. Alter与其同事在Lancet发表论文,报告输血相关肝炎的临床和血清学分析,有8例是“非A非B(非甲肝非乙肝)”肝炎。1978年Alter和他的同事们发现,这些肝炎患者的血液可能会把这种疾病传染给黑猩猩。这说明这种输血性肝炎具有传染性。Alter的系统研究发现了一种新的独特的慢性病毒性肝炎,Alter小组称其为“非A、非B”型肝炎(起初命名类似非典,后来命名为丙肝)。如果从1970年算起,至今已经有50年了,哈维·J·阿尔特在探索丙肝病毒研究的征程中,他类似于马拉松长跑的领跑者,与他人合作,接力赛跑,50年如一日,至今奔跑前进的步伐从未减慢。看看近十年的新作,方知进入耄耋之年的哈维·J·阿尔特是怎样对待科学研究,怎样对待丙肝研究的。














From B to Non-B to C: The Hepatitis C Virus in Historical Perspective

Harvey J. Alter

2019, HCV: The Journey from Discovery to a Cure - Chapter

The discovery of HCV was an evolutionary process beginning with the serendipitous identification of the Australia antigen that later proved to be the surface protein of the hepatitis B virus (HBV) and...more





Circulating let-7 levels in serum correlate with the severity of hepatic fibrosis in chronic hepatitis C

Kentaro Matsuura, Nobuhiro Aizawa, Hirayuki Enomoto, Shuhei Nishiguchi, Hidenori Toyoda, Takashi Kumada, Etsuko Iio, Kyoko Ito, Shintaro Ogawa, Masanori Isogawa, Harvey J Alter, Yasuhito Tanaka

2018, Open Forum Infectious Diseases - Article

Background: Evaluating the progression of hepatic fibrosis in chronic hepatitis C (CHC) is critical, and identifying a predictive biomarker for fibrosis will be helpful for implementing personalized s...more













Hepatitis E Virus Does Not Contribute to Hepatic Decompensation Among Patients With Advanced Chronic Hepatitis C

Niharika Samala, Elizabeth C. Wright, A. Gretchen Buckler, Vanessa Vargas, Kirti Shetty, K. Rajender Reddy, Michael R. Lucey, Harvey J. Alter, Jay H. Hoofnagle, Marc G. Ghany

2016, Clinical Gastroenterology and Hepatology - Article

BACKGROUND & AIMS: <AbstractText Label="BACKGROUND &amp; AIMS">Hepatitis E (HEV) can cause acute-on-chronic liver failure in persons with pre-existing liver disease. We investi...more



Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification

Hui Li, Mark B. Stoddard, Shuyi Wang, Elena E. Giorgi, Lily M. Blair, Gerald H. Learn, Beatrice H. Hahn, Harvey J. Alter, Michael P. Busch, Daniel S. Fierer, Ruy M. Ribeiro, Alan S. Perelson, Tanmoy Bhattacharya, George M. Shaw

2016, Journal of Virology - Article

Despite the recent development of highly effective anti-hepatitis C virus (HCV) drugs, the global burden of this pathogen remains immense. Control or eradication of HCV will likely require the broad a...more



Inherent transcriptional signatures of NK cells are associated with response to IFNα + rivabirin therapy in patients with Hepatitis C Virus

Maria Libera Ascierto, Federica Bozzano, Davide Bedognetti, Francesco Marras, Cathy Schechterly, Kentaro Matsuura, Antonino Picciotto, Simona Marenco, Yingdong Zhao, Valeria DeGiorgi, Michele Sommariva, Lorenzo Moretta, Ena Wang, Harvey J Alter, Francesco M Marincola, Andrea De Maria

2015, Journal of Translational Medicine - Article

BACKGROUND: Differences in the expression of Natural Killer cell receptors have been reported to reflect divergent clinical courses in patients with chronic infections or tumors. However, extensive mo...more



An Epidemiologic Investigation of a Case of Acute Hepatitis E

Souvik Sarkar, Elenita M. Rivera, Ronald E. Engle, Hanh T. Nguyen, Cathy A. Schechterly, Harvey J. Alter, T. Jake Liang, Robert H. Purcell, Jay H. Hoofnagle, Marc G. Ghany

2015, Journal of Clinical Microbiology - Article

Hepatitis E virus (HEV) is considered a zoonotic infection in developed nations. A case of acute hepatitis E in a researcher following a scalpel injury while working on a pig prompted a seroepidemiolo...more



Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

Jens Bukh, Ronald E. Engle, Kristina Faulk, Richard Y. Wang, Patrizia Farci, Harvey J. Alter, Robert H. Purcell

2015, Journal of Virology - Article

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected pa...more



Transfusion‐associated hepatitis before the screening of blood for hepatitis risk factors

Ronald E. Engle, Jens Bukh, Harvey J. Alter, Suzanne U. Emerson, Joni L. Trenbeath, Hanh T. Nguyen, Alicia Brockington, Tanaji Mitra, Robert H. Purcell

2014, Transfusion - Article

BACKGROUND: The true incidence of transfusion-associated hepatitis (TAH) before blood screening is unknown. Our aims were to reevaluate blood recipients receiving unscreened blood and analyze hepatiti...more



Differential Responses of Plasmacytoid Dendritic Cells to Influenza Virus and Distinct Viral Pathogens

Jaime M. Thomas, Zoltan Pos, Jennifer Reinboth, Richard Y. Wang, Ena Wang, Gregory M. Frank, Paolo Lusso, Giorgio Trinchieri, Harvey J. Alter, Francesco M. Marincola, Emmanuel Thomas

2014, Journal of Virology - Article

Plasmacytoid dendritic cells (pDCs) are key components of the innate immune response that are capable of synthesizing and rapidly releasing vast amounts of type I interferons (IFNs), particularly IFN-...more







Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis

Mazen Noureddin, Elizabeth C. Wright, Harvey J. Alter, Shauna Clark, Emmanuel Thomas, Richard Chen, Xiongce Zhao, Cathy Conry‐Cantilena, David E. Kleiner, T. Jake Liang, Marc G. Ghany

2013, Hepatology - Article

Interleukin (IL)28B polymorphisms are associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to therapy. Whether IL28B genotype affects fibrosis progression or clinica...more



An assessment of hepatitis E virus (HEV) in US blood donors and recipients: no detectable HEV RNA in 1939 donors tested and no evidence for HEV transmission to 362 prospectively followed recipients

Chenyu Xu, Richard Y. Wang, Cathy A. Schechterly, Shengxiang Ge, James W. Shih, Ning‐Shao Xia, Naomi L.C. Luban, Harvey J. Alter

2013, Transfusion - Article

BACKGROUND: Hepatitis E virus (HEV) infection has become relevant to blood transfusion practice because isolated cases of blood transmission have been reported and because HEV has been found to cause ...more





Evolutionary analysis of hepatitis C virus gene sequences from 1953

Rebecca R. Gray, Yasuhito Tanaka, Yutaka Takebe, Gkikas Magiorkinis, Zelma Buskell, Leonard Seeff, Harvey J. Alter, Oliver G. Pybus

2013, Philosophical Transactions of the Royal Society B Biological Sciences - Article

Reconstructing the transmission history of infectious diseases in the absence of medical or epidemiological records often relies on the evolutionary analysis of pathogen genetic sequences. The precisi...more









Investigation of residual hepatitis C virus in presumed recovered subjects

Kei Fujiwara, Robert D. Allison, Richard Y. Wang, Patricia Bare, Kentaro Matsuura, Cathy Schechterly, Krishna Murthy, Francesco M. Marincola, Harvey J. Alter

2013, Hepatology - Article

Recent studies have found hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of the majority of presumed recovered subjects. We investigated this unexpected finding using sample...more



A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

Harvey J. Alter, Judy A. Mikovits, William M. Switzer, Francis W. Ruscetti, Shyh-Ching Lo, Nancy Klimas, Anthony L. Komaroff, Jose G. Montoya, Lucinda Bateman, Susan Levine, Daniel Peterson, Bruce Levin, Maureen R. Hanson, Afia Genfi, Meera Bhat, HaoQiang Zheng, Richard Wang, Bingjie Li, Guo-Chiuan Hung, Li Ling Lee, Stephen Sameroff, Walid Heneine, John Coffin, Mady Hornig, W. Ian Lipkin

2012, mBio - Article

The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related vir...more





Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis

Patrizia Farci, Kurt Wollenberg, Giacomo Diaz, Ronald E. Engle, Maria Eliana Lai, Paul Klenerman, Robert H. Purcell, Oliver G. Pybus, Harvey J. Alter

2012, Proceedings of the National Academy of Sciences of the United States of America - Article

Chronic hepatitis C may follow a mild and stable disease course or progress rapidly to cirrhosis and liver-related death. The mechanisms underlying the different rates of disease progression are unkno...more



A 25-Year Study of the Clinical and Histologic Outcomes of Hepatitis C Virus Infection and Its Modes of Transmission in a Cohort of Initially Asymptomatic Blood Donors

Robert D. Allison, Cathy Conry-Cantilena, Deloris Koziol, Cathy Schechterly, Paul Ness, Joan Gibble, David E. Kleiner, Marc G. Ghany, Harvey J. Alter

2012, The Journal of Infectious Diseases - Article

BACKGROUND: A total of 738 volunteer blood donors who were positive for anti-hepatitis C virus (HCV) were assessed for risk factors and outcomes for up to 15 years within the study and up to 54 years ...more



The clinical relevance of persistent recombinant immunoblot assay–indeterminate reactions: insights into the natural history of hepatitis C virus infection and implications for donor counseling

Addisalem T. Makuria, Sukanya Raghuraman, Peter D. Burbelo, Cathy C. Cantilena, Robert D. Allison, Joan Gibble, Barbara Rehermann, Harvey J. Alter

2012, Transfusion - Article

BACKGROUND: Recombinant immunoblot assay (RIBA) is used to determine the specificity of antibody to hepatitis C virus (anti-HCV). The RIBA result is recorded as positive, negative, or indeterminate. T...more



Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes

Michael P. Busch, Krishna K. Murthy, Steven H. Kleinman, Dale F. Hirschkorn, Belinda L. Herring, Eric L. Delwart, Vito Racanelli, Joo Chun Yoon, Barbara Rehermann, Harvey J. Alter

2012, Blood - Article

Serial plasma aliquots (50 mL) obtained from 10 commercial donors who converted from hepatitis C virus (HCV) RNA negative to positive were transfused into 2 chimpanzees to assess infectivity during ea...more



Absence of transfusion‐associated microchimerism in pediatric and adult recipients of leukoreduced and gamma‐irradiated blood components

Rosa Sanchez, Tzong‐Hae Lee, Li Wen, Leilani Montalvo, Cathy Schechterly, Camilla Colvin, Harvey J. Alter, Naomi L.C. Luban, Michael P. Busch

2012, Transfusion - Article

BACKGROUND: Transfusion-associated microchimerism (TA-MC), the persistence of significant levels of donor white blood cells (WBCs) in blood recipients for prolonged periods, has been demonstrated afte...more









Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study

Graham Simmons, Simone A. Glynn, Anthony L. Komaroff, Judy A. Mikovits, Leslie H. Tobler, John Hackett, Ning Tang, William M. Switzer, Walid Heneine, Indira K. Hewlett, Jiangqin Zhao, Shyh-Ching Lo, Harvey J. Alter, Jeffrey M. Linnen, Kui Gao, John M. Coffin, Mary F. Kearney, Francis W. Ruscetti, Max A. Pfost, James Bethel, Steven Kleinman, Jerry A. Holmberg, Michael P. Busch, for the Blood XMRV Scientific Research Working Group

2011, Science - Article

Murine leukemia viruses (MLVs), including xenotropic-MLV-related virus (XMRV), have been controversially linked to chronic fatigue syndrome (CFS). To explore this issue in greater depth, we compiled c...more



The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes

R. Loomba, M. M. Rivera, R. McBurney, Y. Park, V. Haynes‐Williams, B. Rehermann, H. J. Alter, S. K. Herrine, T. J. Liang, J. H. Hoofnagle, T. Heller

2011, Alimentary Pharmacology & Therapeutics - Article

BACKGROUND: Acute hepatitis C has variable modes of presentation and frequently results in chronic infection. Its optimal management has yet to be defined. AIM: To establish natural history and compli...more





Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors

Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. Komaroff, Guo-Chiuan Hung, Richard Wang, Harvey J. Alter

2010, Proceedings of the National Academy of Sciences of the United States of America - Article

Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclea...more



Parvovirus B19 infection transmitted by transfusion of red blood cells confirmed by molecular analysis of linked donor and recipient samples

Mei‐ying W. Yu, Harvey J. Alter, Maria Luisa A. Virata‐Theimer, Yansheng Geng, Li Ma, Cathy A. Schechterly, Camilla A. Colvin, Naomi L.C. Luban

2010, Transfusion - Article

BACKGROUND: Extremely high viremic levels of parvovirus B19 (B19V) can be found in acutely infected, but asymptomatic donors. However, reports of transmission by single-donor blood components are rare...more





Genomic scale analysis of racial impact on response to IFN-α

Zoltan Pos, Silvia Selleri, Tara L. Spivey, Jeanne K. Wang, Hui Liu, Andrea Worschech, Marianna Sabatino, Alessandro Monaco, Susan F. Leitman, Andras Falus, Ena Wang, Harvey J. Alter, Francesco M. Marincola

2010, Proceedings of the National Academy of Sciences of the United States of America - Article

Limited responsiveness to IFN-alpha in hepatitis C virus (HCV)-infected African-Americans compared to European Americans (AAs vs. EAs) hinders the management of HCV. Here, we studied healthy non-HCV-i...more





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