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Thieme的开放存取期刊及精华摘引

已有 743 次阅读 2017-9-12 17:25 |个人分类:新观察|系统分类:论文交流|关键词:OA期刊,摘引

Thieme的开放存取期刊及精华摘引

诸平

Thieme Open Access Journals

Directed Evolution toward an Iron-Heme Enzyme for Asymmetric C–H Amination

Prier CK. Zhang RK. Buller AR. Brinkmann-Chen S. Arnold FH. * California Institute of Technology, Pasadena, USA
Enantioselective, Intermolecular Benzylic C–H Amination Catalysed by an Engineered Iron-Haem Enzyme
Nat. Chem. 2017, 9, 629–634.

Significance: The authors discovered that P-4, a P450BM3 variant with 17 mutations from the wildtype, catalyzes the benzylic C–H amination of 4-ethylanisole, albeit with low enantioselectivity. Through sequential rounds of site-selective mutagenesis, P-411CHA was found to dramatically improve the yield and enantioselectivity of the reaction for a wide range of electronically-differentiated substrates. X-ray crystallography showed that all of the beneficial mutations lie within the active site of the enzyme.

Interview with Jianhui Huang
This Young Career Focus presents Jianhui Huang (Tianjin University, P. R. of China).

Total Synthesis of Ovafolinins A and B
David Barker describes the formation of polycyclic benzoxepin lignans through a cascade cyclization.

Direct Asymmetric Bromotrifluoromethoxylation of Alkenes
Pingping Tang reports the use of trifluoromethyl arylsulfonate as a new trifluoromethoxylation reagent.




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